意大利监狱环境中 HIV 感染者女性：基于特定性别 ROSE 网络的研究结果。

Women Living with HIV in Italian Prison Settings: Results from the Gender-Specific ROSE Network.

机构信息

Medicina Protetta-Unit of Infectious Diseases, Belcolle Hospital, 01100 Viterbo, Italy.

Infectious and Tropical Disease Clinic, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.

出版信息

Viruses. 2023 Feb 10;15(2):497. doi: 10.3390/v15020497.

DOI:10.3390/v15020497

PMID:36851711

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9968113/

Abstract

BACKGROUND

Incarcerated women are a minority in the Italian prison population. The lack of prevention and awareness of HIV infection and the lack of access to treatment make the treatment path difficult.

METHODS

we conducted a multi-center study including incarcerated women living with HIV (WLWH).

RESULTS

The study included 85 WLWH with a mean age of 41.7 ± 8.7 years, and 58.8% (50/85) of them were Italian. Principally, HIV transmission was related to sexual intercourse, 47% of all patients were PWIDs, and 62.5% of them were on opioid substitution therapy (OST). Overall, 56.4% of the included patients had a CD4+ cell count of >500 cells/mmc. Among the participants, 92.9% were on antiretroviral therapy, 87.3% had treatment before incarceration, and 83.5% were virologically suppressed. Among the 13 non-virally-suppressed patients, 53.8% were unaware of their serological status before incarceration and had started HAART but were still not virologically suppressed; 46.2% (6/13) had a lack of compliance or had suspended the treatment before incarceration and restarted it after admission. All patients with chronic hepatitis C underwent treatment with direct-acting antivirals and reached a sustained virological response.

CONCLUSIONS

the detention of these women could represent an occasion for the patients' healthcare provision and use, and the creation of a gender-specific network can be an effective strategy for reaching this population.

摘要

背景

在意大利监狱人口中，女性囚犯占少数。由于缺乏预防和艾滋病感染意识，以及治疗途径不畅，导致治疗困难。

方法

我们进行了一项多中心研究，纳入了感染艾滋病毒的女性囚犯（WLWH）。

结果

该研究纳入了 85 名 WLWH，平均年龄为 41.7 ± 8.7 岁，其中 58.8%（50/85）为意大利人。HIV 主要通过性传播感染，所有患者中有 47%为注射吸毒者，其中 62.5%接受阿片类药物替代治疗（OST）。总体而言，56.4%的纳入患者 CD4+细胞计数>500 个/立方毫米。在参与者中，92.9%接受抗逆转录病毒治疗，87.3%在入狱前接受过治疗，83.5%病毒学抑制。在 13 名未病毒学抑制的患者中，53.8%在入狱前不知道自己的血清学状态，开始接受 HAART 但仍未病毒学抑制；46.2%（6/13）在入狱前不遵守或暂停治疗，然后在入院后重新开始。所有慢性丙型肝炎患者均接受直接作用抗病毒药物治疗，并达到持续病毒学应答。