Kardynska Malgorzata, Kogut Daria, Pacholczyk Marcin, Smieja Jaroslaw
Dept. of Biosensors and Processing of Biomedical Signals, Silesian University of Technology, Gliwice, Poland.
Dept. of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland.
Comput Struct Biotechnol J. 2023 Feb 8;21:1523-1532. doi: 10.1016/j.csbj.2023.02.006. eCollection 2023.
Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly supported by modeling, analytical and computational techniques as well as discrete mathematics and artificial intelligence applied to to extract knowledge from existing databases. This review is focused on mathematical modeling used to analyze dynamics and robustness of these networks. This paper presents a review of selected modeling methods that facilitate advances in molecular biology.
调节网络结构和信号通路动态是在耗时且耗费资源的实验工作中揭示出来的。然而，它越来越多地得到建模、分析和计算技术以及应用离散数学和人工智能从现有数据库中提取知识的支持。本综述聚焦于用于分析这些网络动态和稳健性的数学建模。本文介绍了一些有助于分子生物学取得进展的选定建模方法。
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