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Erdheim-Chester病：一例具有罕见表现及治疗挑战的多系统疾病病例说明

Erdheim-Chester disease: A multisystem disease case illustration with rare manifestations and treatment challenges.

作者信息

Jridi Maysam, Ben Achour Tayssir, Naceur Ines, Smiti Monia, Ben Ghorbel Imed, Lamloum Mounir, Said Fatma, Houman Mohamed Habib

机构信息

Rabta University Hospital Center Tunis Tunisia.

出版信息

Clin Case Rep. 2023 Feb 24;11(2):e6996. doi: 10.1002/ccr3.6996. eCollection 2023 Feb.

DOI:10.1002/ccr3.6996
PMID:36852124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9957994/
Abstract

Erdheim-Chester disease is a rare multisystemic disease. A 50-year-old woman, presented with a recurrent pain and swelling of the left knee. Bone scintigraphy showed increased tracer uptake of peripheral skeleton. The computed tomography showed tissular infiltration in the retroperitoneum, around the vessels. Immunohistochemistry showed CD68 (+) and CD1a (-).

摘要

厄尔德海姆-切斯特病是一种罕见的多系统疾病。一名50岁女性，出现左膝反复疼痛和肿胀。骨闪烁显像显示外周骨骼示踪剂摄取增加。计算机断层扫描显示腹膜后、血管周围有组织浸润。免疫组织化学显示CD68（+）和CD1a（-）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/6d6d7a1c5b09/CCR3-11-e6996-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/a4242131be54/CCR3-11-e6996-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/7395f61680c3/CCR3-11-e6996-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/6d6d7a1c5b09/CCR3-11-e6996-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/a4242131be54/CCR3-11-e6996-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/7395f61680c3/CCR3-11-e6996-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6141/9957994/6d6d7a1c5b09/CCR3-11-e6996-g002.jpg

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本文引用的文献

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Br J Haematol. 2021 Sep;194(6):1024-1033. doi: 10.1111/bjh.17712. Epub 2021 Aug 22.
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Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era.骨硬化性嗜酸性肉芽肿：分子时代下的评估、诊断和治疗的共识建议。
Blood. 2020 May 28;135(22):1929-1945. doi: 10.1182/blood.2019003507.
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Erdheim-Chester disease.
额颞叶痴呆。
Blood. 2020 Apr 16;135(16):1311-1318. doi: 10.1182/blood.2019002766.
4
The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease.梅奥诊所组织细胞增生症工作组共识声明：成人组织细胞肿瘤的诊断和评估——Erdheim-Chester 病、朗格汉斯细胞组织细胞增生症和 Rosai-Dorfman 病。
Mayo Clin Proc. 2019 Oct;94(10):2054-2071. doi: 10.1016/j.mayocp.2019.02.023. Epub 2019 Aug 28.
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Orphanet J Rare Dis. 2019 Jan 10;14(1):11. doi: 10.1186/s13023-018-0988-y.
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