Wu Kathie, Bhattacharya Prianka
Internal Medicine, Geisinger Medical Center, Danville, USA.
Hematology/Oncology, Geisinger Medical Center, Danville, USA.
Cureus. 2023 Jan 26;15(1):e34232. doi: 10.7759/cureus.34232. eCollection 2023 Jan.
5-fluorouracil (5-FU) has been known to have cardiotoxic side effects, including coronary vasospasm, myocardial infarctions, heart failure, arrhythmias, and cardiac arrest. These cases have been reported in patients with either known coronary disease or known risk factors. In cases of acute cardiotoxicity, cessation of fluoropyrimidines is recommended, and reintroduction of the medication is generally avoided. We present a case of a young patient with no known risk factors for coronary disease, who presented with an acute cardiac arrest suspected secondary to vasospasm from the administration of 5-FU for the treatment of rectal cancer and was successfully maintained on treatment with 5-FU post-arrest after transitioning from an infusion to bolus administration.
已知5-氟尿嘧啶（5-FU）具有心脏毒性副作用，包括冠状动脉痉挛、心肌梗死、心力衰竭、心律失常和心脏骤停。这些病例在患有已知冠状动脉疾病或已知风险因素的患者中均有报道。在急性心脏毒性的情况下，建议停用氟嘧啶，并且通常避免重新使用该药物。我们报告了一例年轻患者，该患者无已知的冠状动脉疾病风险因素，因直肠癌接受5-FU治疗后疑似因血管痉挛继发急性心脏骤停，在从静脉输注改为推注给药后，心脏骤停后成功继续使用5-FU进行治疗。
