Albright N
Department of Radiation Oncology, University of California, San Francisco 94143.
Radiat Res. 1987 Nov;112(2):331-40.
Four programs have been written to enable radiobiologists to build a computer data base of cellular dose-survival data, calculate cell survival with a correction for cell multiplicity at the time of irradiation, fit various survival models to the data by iteratively weighted least squares, and calculate the ratio of survival levels corresponding to specified doses or the ratio of doses that produce specified survival levels (e.g., oxygen enhancement ratio or relative biological effectiveness). The programs make plots of survival curves and data, and they calculate standard errors and confidence intervals of the fitted survival curve parameters and ratios. The programs calculate survival curves for the linear-quadratic, repair-saturation, single-hit multitarget, linear-multitarget, and repair-misrepair models of cell survival and have been designed to accommodate the addition of other survival models in the future. The programs can be used to compare the accuracy with which different models fit the data, determine if a difference in fit is statistically significant, and show how the estimated value of a survival curve parameter, such as the extrapolation number or the final slope, varies with the survival model. The repair of radiation-induced damage is analyzed in a novel way using these programs.
现已编写了四个程序，使放射生物学家能够建立一个细胞剂量-存活数据的计算机数据库，在考虑照射时细胞多重性校正的情况下计算细胞存活率，通过迭代加权最小二乘法将各种存活模型拟合到数据中，并计算对应于指定剂量的存活水平之比或产生指定存活水平的剂量之比（例如，氧增强比或相对生物效能）。这些程序可绘制存活曲线和数据图，并计算拟合存活曲线参数和比值的标准误差及置信区间。这些程序能针对细胞存活的线性二次模型、修复饱和模型、单击多靶模型、线性多靶模型和修复-错配模型计算存活曲线，并且设计为未来可容纳其他存活模型。这些程序可用于比较不同模型拟合数据的准确性，确定拟合差异是否具有统计学显著性，并展示存活曲线参数（如外推数或最终斜率）的估计值如何随存活模型而变化。利用这些程序以一种全新的方式分析了辐射诱导损伤的修复情况。
