治疗性、人源化单克隆抗体对鲍曼不动杆菌具有广泛的结合和保护效力。
Therapeutic, Humanized Monoclonal Antibody Exhibits Broad Binding and Protective Efficacy against Acinetobacter baumannii.
机构信息
Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Los Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA.
出版信息
Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0008623. doi: 10.1128/aac.00086-23. Epub 2023 Feb 28.
Abstract
Acinetobacter baumannii is an extremely drug-resistant pathogen necessitating the development of new therapies. We seek to generate a cocktail of monoclonal antibodies (MAbs) that can target the full diversity of A. baumannii isolates. We have newly identified the antibody MAb5. Here, we demonstrate that MAb5 has broad binding against U.S. ( = 300) and international ( = 250) isolates (72.24% and 28.76%, respectively), likely targets O-antigen capsular carbohydrates, and exhibits protective efficacy .
摘要
鲍曼不动杆菌是一种具有极强耐药性的病原体，需要开发新的治疗方法。我们试图生成一种可以针对鲍曼不动杆菌分离株的全部多样性的单克隆抗体（MAb）混合物。我们新鉴定出了抗体 MAb5。在这里，我们证明 MAb5 对美国（ = 300）和国际（ = 250）分离株具有广泛的结合活性（分别为 72.24%和 28.76%），可能靶向 O-抗原荚膜碳水化合物，并表现出保护效力。
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