de Souza Raquel Eustaquia, Quispe Mendoza Isabel Yovana, Reis Adriano Max Moreira, Tavares João Paulo de Almeida, Guimarães Gilberto de Lima, Simino Giovana de Paula Rezende, Moura Ravena Rieelly Araújo, da Silva Silmar Maria
Municipal Health Department, Contagem, Minas Gerais, Brazil (Ms de Souza); Basic Nursing Department, School of Nursing, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Drs Quispe Mendoza, Guimarães, Simino, and da Silva); Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais Belo Horizonte, Minas Gerais, Brazil (Reis); Higher School of Health, University of Aveiro, Aveiro, Portugal (Dr Tavares); Campus Betim, Pitágoras College, Minas Gerais, Brazil (Ms Moura).
Raquel Eustaquia de Souza, MS, received her Master's degree from the Nursing School of Federal University of Minas Gerais (2020). Deputy Director of the Minas Gerais Society of Thanatology and Palliative Care, she is a technical reference for older adult health and primary care in the municipality of Contagem.
J Infus Nurs. 2023;46(2):107-115. doi: 10.1097/NAN.0000000000000496.
This study aimed to analyze the factors associated with local adverse effects resulting from hypodermoclysis in older adult patients in palliative care. The study involved 127 older adults undergoing palliative care at a hospital in southeastern Brazil. Data collection was performed from August to November 2019. Patients aged 60 years or older, with a prescription for hypodermoclysis at the time of admission and who were not receiving hypodermoclysis at the time of admission, were included. Data collected included sociodemographic, clinical, pharmacotherapeutic, and adverse effects of hypodermoclysis administration. Most participants were women (59.0%), with a mean age of 78.5 years. Frailty was the most prevalent diagnosis (26.8%), and 80.2% of patients were in the end-of-life stage. There was an incidence of 24.0% of adverse events, with catheter obstruction and swelling in the surrounding area of the hypodermoclysis site being the most frequent at 11.3% and 8.5%, respectively. Ondansetron administration by hypodermoclysis was 3 times more likely to have an adverse effect compared to not using this drug. In contrast, a protective factor was evident with the administration of 0.9% sodium chloride, which contributed to the reduction of complications. The occurrence of adverse effects from hypodermoclysis in the study population of older adults in palliative care was low.
本研究旨在分析姑息治疗中老年患者皮下输液所致局部不良反应的相关因素。该研究纳入了巴西东南部一家医院接受姑息治疗的127名老年人。数据收集于2019年8月至11月进行。纳入标准为年龄60岁及以上、入院时开具皮下输液处方且入院时未接受皮下输液的患者。收集的数据包括社会人口学、临床、药物治疗以及皮下输液给药的不良反应等方面。大多数参与者为女性（59.0%），平均年龄为78.5岁。虚弱是最常见的诊断（26.8%），80.2%的患者处于临终阶段。不良事件发生率为24.0%，皮下输液部位导管堵塞和周围区域肿胀最为常见，分别为11.3%和8.5%。与未使用昂丹司琼相比，皮下注射昂丹司琼发生不良反应的可能性高3倍。相比之下，使用0.9%氯化钠具有明显的保护作用，有助于减少并发症。在姑息治疗的老年研究人群中，皮下输液不良反应的发生率较低。
