较高的牛奶摄入量与降低骨折风险无关：系统评价与荟萃分析。
Higher milk consumption is not associated with fracture risk reduction: systematic review and meta-analysis.
作者信息
Goncerz Grzegorz, Kojm Patrycja, Skocelas Sylwia, Więckowski Krzysztof, Gallina Tomasz, Pietrzyk Paulina, Goncerz Sebastian
机构信息
Department of Anatomy, Jagiellonian University Medical College; Polish Institute of Evidence Based Medicine, Kraków, Poland.
Jagiellonian University Medical College, Kraków, Poland.
出版信息
Folia Med Cracov. 2022 Dec 29;62(4):137-153.
INTRODUCTION
Osteoporosis affects over 200 million people worldwide causing nearly 9 million fractures annually, with more than half in America and Europe.
OBJECTIVES
This meta-analysis was conducted to investigate whether low milk intake is associated with an increased risk of fractures by summarizing all the available evidence.
METHODS
Relevant studies were identified by searching the PubMed and EMBASE databases up to June 2020. The pooled relative risks with 95% confidence intervals were calculated.
RESULTS
In a meta-regression analysis of 20 included studies (11 cohort and 9 case-control studies), a higher milk intake was not associated with a reduction in the total fracture risk in both sexes (OR 0.95, 95% CI: 0.84- 1.08), either in cohort (OR 0.91; 95% CI: 0.79-1.05) or case-control studies (OR 1.09; 95% CI: 0.82-1.44), as well as separately in men (OR 0.87; 95% CI: 0.71-1.07) and women (OR 0.95; 95% CI: 0.80-1.13).
CONCLUSION
Higher milk consumption is not associated with fracture risk reduction and should not be recommended for fracture prevention.
引言
骨质疏松症影响着全球超过2亿人，每年导致近900万例骨折，其中一半以上发生在美国和欧洲。
目的
本荟萃分析旨在通过总结所有现有证据，研究低牛奶摄入量是否与骨折风险增加有关。
方法
通过检索截至2020年6月的PubMed和EMBASE数据库来识别相关研究。计算合并的相对风险及95%置信区间。
结果
在对20项纳入研究（11项队列研究和9项病例对照研究）的荟萃回归分析中，较高的牛奶摄入量与男女总体骨折风险降低无关（比值比0.95，95%置信区间：0.84 - 1.08），在队列研究（比值比0.91；95%置信区间：0.79 - 1.05）或病例对照研究（比值比1.09；95%置信区间：0.82 - 1.44）中均如此，在男性（比值比0.87；95%置信区间：0.71 - 1.07）和女性（比值比0.95；95%置信区间：0.80 - 1.13）中单独分析时也是如此。
结论
较高的牛奶消费量与骨折风险降低无关，不建议用于预防骨折。
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