From the Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain.
Department of Pediatrics, Sheikh Khalifa Medical City, Abu Dhabi.
Pediatr Infect Dis J. 2023 Jun 1;42(6):515-519. doi: 10.1097/INF.0000000000003883. Epub 2023 Feb 24.
The literature describing clinical presentation, disease course and outcomes of SARS-CoV-2 in infants remains scarce.
We conducted a retrospective study across 2 major pediatric referral centers evaluating the demographics, clinical and laboratory characteristics, management and outcomes of COVID-19 among newborns and infants in the United Arab Emirates (UAE). Clinical and biochemical markers were evaluated for their accuracy in predicting intensive care unit (ICU) transfer and death.
A total of 576 COVID-19-positive infants were evaluated with a mean age of 164 days. The mean duration of symptoms was 1.48 days. Fever was present in 36.5% of the cohort, while 44.3% had nasal congestion. Eight infants (of 575; 1.39%) required transfer to the ICU for impending respiratory failure and 2 required invasive ventilation. Symptomatic (fever, nasal congestion) infants were not more likely to be transferred to the ICU (Chi-squared test, P = 0.77). ICU transfer was associated with a higher chance of receiving antibiotics (70.6% vs 35.4%; Chi-squared test, P = 0.003). On multivariate analysis, none of the clinical parameters (age, symptoms, laboratory tests) predicted transfer to the ICU. No deaths were reported during the observation period.
Infants with SARS-CoV-2 infection have a benign clinical course with favorable outcomes. Less than 2% require ICU transfer. Clinical vigilance is required as none of the admission parameters predicted ICU transfer.
描述 SARS-CoV-2 在婴儿中的临床表现、疾病过程和结局的文献仍然很少。
我们在阿联酋的 2 家主要儿科转诊中心进行了一项回顾性研究，评估了 COVID-19 在阿联酋新生儿和婴儿中的人口统计学、临床和实验室特征、管理和结局。评估了临床和生化标志物在预测转入重症监护病房（ICU）和死亡方面的准确性。
共评估了 576 例 COVID-19 阳性婴儿，平均年龄为 164 天。症状平均持续 1.48 天。发热患儿占 36.5%，鼻塞患儿占 44.3%。8 例（575 例中的 1.39%）婴儿因即将发生呼吸衰竭而需要转入 ICU，2 例需要有创通气。有症状（发热、鼻塞）的婴儿转入 ICU 的可能性更小（卡方检验，P=0.77）。转入 ICU 与更有可能使用抗生素相关（70.6% vs 35.4%；卡方检验，P=0.003）。多变量分析显示，没有任何临床参数（年龄、症状、实验室检查）可以预测转入 ICU。在观察期间没有死亡报告。
感染 SARS-CoV-2 的婴儿具有良性临床过程和良好的结局。不到 2%的患儿需要转入 ICU。由于入院参数均不能预测 ICU 转科，因此需要进行临床监测。
