Bouman Emma J, Beulens Joline W J, den Braver Nicolette R, Blom Marieke T, Remmelzwaal Sharon, Elders Petra J M, Rutters Femke
Epidemiology and Data Science, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Amsterdam Public Health, Health Behaviors & Chronic Diseases, Amsterdam, the Netherlands.
Obesity (Silver Spring). 2023 Apr;31(4):945-954. doi: 10.1002/oby.23730. Epub 2023 Feb 28.
Social jet lag, i.e., the discordance among social and biological rhythms, is associated with poor metabolic control. This study aimed to assess cross-sectional and longitudinal associations among social jet lag and glycemic and metabolic control in people with type 2 diabetes.
In a prospective cohort (N = 990) with type 2 diabetes, social jet lag was measured at baseline using daily diaries and was categorized (high, moderate, or low). Metabolic outcomes were assessed at baseline and at 1 and 2 years of follow-up. Associations among social jet lag and glycemic and metabolic control were analyzed using linear regression and linear mixed models adjusted for confounding factors. Analyses were stratified for work status (retired vs. working; p value for interaction = 0.007 for glycated hemoglobin [HbA1c]).
In working people, a cross-sectional association between high social jet lag and HbA1c (1.87 mmol/mol [95% CI: 0.75 to 2.99]) and blood pressure (5.81 mm Hg [95% CI: 4.04 to 7.59]) was observed. For retired people, high social jet lag was negatively associated with HbA1c (-1.58 mmol/mol [95% CI: -2.54 to -0.62]), glucose (-0.19 mmoL/L [95% CI:-0.36 to -0.01]), and blood pressure (-3.70 mm Hg [95% CI: -5.36 to -2.04]), and the association with BMI was positive (1.12 kg/m [95% CI: 0.74 to 1.51]). Prospective associations had the same direction as cross-sectional findings but were nonsignificant for working or retired people.
Social jet lag was cross-sectionally, but not prospectively, associated with glycemic and metabolic markers. Interaction with work status was present, and directions of the associations were generally detrimental in the working population, whereas higher social jet lag was associated with improved glycemic and metabolic control for retired people.
社会时差，即社交和生物节律之间的不一致，与代谢控制不佳有关。本研究旨在评估2型糖尿病患者中社会时差与血糖和代谢控制之间的横断面和纵向关联。
在一个2型糖尿病前瞻性队列（N = 990）中，使用每日日记在基线时测量社会时差，并进行分类（高、中或低）。在基线以及随访1年和2年时评估代谢指标。使用线性回归和针对混杂因素进行调整的线性混合模型分析社会时差与血糖和代谢控制之间的关联。分析按工作状态分层（退休与在职；糖化血红蛋白[HbA1c]的交互作用p值 = 0.007）。
在职人群中，观察到高社会时差与HbA1c（1.87 mmol/mol [95%CI：0.75至2.99]）和血压（5.81 mmHg [95%CI：4.04至7.59]）之间存在横断面关联。对于退休人群，高社会时差与HbA1c（-1.58 mmol/mol [95%CI：-2.54至-0.62]）、血糖（-0.19 mmol/L [95%CI：-0.36至-0.01]）和血压（-3.70 mmHg [95%CI：-5.36至-2.04]）呈负相关，与BMI的关联为正（1.12 kg/m [95%CI：0.74至1.51]）。前瞻性关联与横断面研究结果方向相同，但在职或退休人群中均无统计学意义。
社会时差与血糖和代谢指标存在横断面关联，但不存在前瞻性关联。存在与工作状态的交互作用，在在职人群中关联方向通常是有害的，而对于退休人群，较高的社会时差与改善的血糖和代谢控制相关。
