Department of Laboratory, Taipei City Hospital, Yang-Ming Branch, Taipei, Taiwan.
Department of Internal Medicine, Taipei City Hospital, Yang-Ming Branch, Taipei, Taiwan.
PeerJ. 2023 Feb 23;11:e14859. doi: 10.7717/peerj.14859. eCollection 2023.
The emerging Vancomycin-resistant (VRE-fm) is an opportunistic pathogen causing nosocomial infections. The identification of VRE-fm is important for successful prevention and control in healthcare settings. VRE-fm clinical isolates obtained from regional hospitals in northern Taiwan were characterized for antimicrobial susceptibility, virulence genes and biofilm production. Most isolates exhibited multi-drug resistance and carried the virulence genes, and . While all isolates produce biofilms, those isolates that carried exhibited greater biofilm production. Isolates with different virulence gene carriages were examined for pathogenicity by using a nematode model, , for determining microbial-host interactions. The survival assay showed that was susceptible to Linezolid-resistant VRE-fm isolates with . Combining the molecular epidemiological profiles regarding pathogenesis in can serve as a guide for physicians in limiting opportunistic infections caused by VRE-fm.
耐万古霉素肠球菌（VRE-fm）的出现是一种机会致病菌，可引起医院感染。在医疗机构中，成功预防和控制 VRE-fm 的关键在于对其进行鉴定。本研究对来自中国台湾北部地区医院的 VRE-fm 临床分离株进行了抗菌药物敏感性、毒力基因和生物膜形成能力的分析。结果显示，大多数分离株表现出多重耐药性，且携带毒力基因 和 。所有分离株均可形成生物膜，而携带 的分离株形成的生物膜更多。通过线虫模型评估不同毒力基因携带分离株的致病性，以确定微生物-宿主相互作用。生存分析表明，对携带 的耐利奈唑烷 VRE-fm 分离株， 敏感。VRE-fm 相关发病机制的分子流行病学特征可作为指导医生限制由 VRE-fm 引起的机会性感染的依据。
