Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan 33302, Taiwan.
Department of Endodontics, Arthur Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94103, USA.
Int J Mol Sci. 2024 Jun 18;25(12):6670. doi: 10.3390/ijms25126670.
Microbes constitute the most prevalent life form on Earth, yet their remarkable diversity remains mostly unrecognized. Microbial diversity in vertebrate models presents a significant challenge for investigating host-microbiome interactions. The model organism has many advantages for delineating the effects of host genetics on microbial composition. In the wild, the gut contains various microbial species, while in the laboratory it is usually a host for a single bacterial species. There is a potential host-microbe interaction between microbial metabolites, drugs, and phenotypes. This mini-review aims to summarize the current understanding regarding the microbiome in . Examples using to study host-microbe-metabolite interactions are discussed.
微生物是地球上最普遍的生命形式，但它们惊人的多样性在很大程度上仍未被认识。脊椎动物模型中的微生物多样性对研究宿主-微生物组相互作用提出了重大挑战。模式生物在描绘宿主遗传对微生物组成的影响方面具有许多优势。在野外，肠道中含有各种微生物物种，而在实验室中，它通常是单一细菌物种的宿主。微生物代谢物、药物和表型之间存在潜在的宿主-微生物相互作用。这篇迷你综述旨在总结目前关于 的微生物组的理解。讨论了使用 来研究宿主-微生物-代谢物相互作用的例子。
