Pesonen Emilia, Nurkkala Marjukka, Niemelä Maisa, Morin-Papunen Laure, Tapanainen Juha S, Jämsä Timo, Korpelainen Raija, Ollila Meri-Maija, Piltonen Terhi T
Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Department of Sports and Exercise Medicine, Oulu Deaconess Institute Foundation, Oulu, Finland.
Obesity (Silver Spring). 2023 Apr;31(4):1108-1120. doi: 10.1002/oby.23681. Epub 2023 Feb 28.
Up to 70% of women with polycystic ovary syndrome (PCOS) have pre-obesity or obesity. The aim of this study was to investigate whether women with PCOS have more weight-loss attempts than women without PCOS, regardless of BMI. Moreover, women's weight perceptions in relation to previous weight-loss attempts were evaluated.
A population-based birth cohort study included women with (n = 278) and without PCOS (control individuals, n = 1560) who were examined at ages 31 and 46 years with questionnaires and clinical examinations.
Women with PCOS had more weight-loss attempts compared with control individuals at age 31 (47% vs. 34%, p < 0.001) and 46 years (63% vs. 47%, p < 0.001). At age 46 years, PCOS was associated with multiple weight-loss attempts in the adjusted model (odds ratio: 1.43 [95% CI: 1.00-2.03], p = 0.05). The perception of having overweight was more prevalent in those with PCOS, even among participants with normal weight, at age 31 (PCOS 47% vs. control 34%, p = 0.014) and 46 years (PCOS 60% vs. control 39%, p = 0.001).
Women with PCOS were more likely to have experienced multiple weight-loss attempts and a perception of having overweight compared with control individuals, regardless of obesity status.
多达70%的多囊卵巢综合征（PCOS）女性存在肥胖前期或肥胖问题。本研究的目的是调查无论体重指数（BMI）如何，患有PCOS的女性是否比未患PCOS的女性有更多的减肥尝试。此外，还评估了女性对以往减肥尝试的体重认知情况。
一项基于人群的出生队列研究纳入了患有PCOS的女性（n = 278）和未患PCOS的女性（对照个体，n = 1560），在她们31岁和46岁时通过问卷调查和临床检查进行了评估。
与对照个体相比，患有PCOS的女性在31岁时减肥尝试更多（47%对34%，p < 0.001），在46岁时也是如此（63%对47%，p < 0.001）。在46岁时，在调整模型中，PCOS与多次减肥尝试相关（优势比：1.43 [95%置信区间：1.00 - 2.03]，p = 0.05）。在31岁（PCOS组47%对对照组34%，p = 0.014）和46岁（PCOS组60%对对照组39%，p = 0.001）时，即使在体重正常的参与者中，PCOS患者中超重的认知也更为普遍。
与对照个体相比，患有PCOS的女性更有可能经历多次减肥尝试且有超重的认知，无论其肥胖状态如何。
