Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
Department of Psychiatry, Isala Hospital, Zwolle, The Netherlands.
Bipolar Disord. 2023 Dec;25(8):683-695. doi: 10.1111/bdi.13313. Epub 2023 Mar 5.
Mental well-being and personal recovery are important treatment targets for patients with bipolar disorder (BD). The goal of this study was to evaluate the effectiveness of an 8-week group multicomponent positive psychology intervention (PPI) for euthymic patients with BD as an adjunct to treatment as usual (TAU) compared to TAU alone.
Patients with BD were randomized to receive TAU (n = 43) or the PPI in addition to TAU (n = 54). The primary outcome was well being measured with the Mental Health Continuum-Short Form. Personal recovery was measured with the Questionnaire about the Process of Recovery. Data were collected at baseline, mid-treatment, post-treatment and 6- and 12-month follow-up. Life chart interviews were conducted at 12 months to retrospectively assess recurrence of depression and mania.
Significant group-by-time interaction effects for well-being and personal recovery were found favouring the PPI. At post-treatment, between-group differences were significant for well-being (d = 0.77) and personal recovery (d = 0.76). Between-group effects for well-being were still significant at 6-month follow-up (d = 0.72). Effects on well-being and personal recovery within the intervention group were sustained until 12-month follow-up. Survival analyses showed no significant differences in time to recurrence.
The multicomponent PPI evaluated in this study is effective in improving mental well-being and personal recovery in euthymic patients with BD and would therefore be a valuable addition to the current treatment of euthymic BD patients. The fact that the study was carried out in a pragmatic RCT demonstrates that this intervention can be applied in a real-world clinical setting.
心理健康和个人康复是双相情感障碍（BD）患者的重要治疗目标。本研究的目的是评估 8 周团体多成分积极心理学干预（PPI）作为常规治疗（TAU）的附加治疗对缓解期 BD 患者的有效性，与仅 TAU 相比。
将 BD 患者随机分为接受 TAU（n=43）或 PPI 加 TAU（n=54）。主要结局是用心理健康连续体-短表测量幸福感。个人康复用康复过程问卷进行评估。数据在基线、治疗中期、治疗后和 6 个月及 12 个月随访时收集。在 12 个月时进行生活图表访谈，以回顾性评估抑郁和躁狂的复发情况。
发现幸福感和个人康复的显著组间时间交互作用有利于 PPI。在治疗后，组间差异在幸福感（d=0.77）和个人康复（d=0.76）方面具有统计学意义。在 6 个月随访时，组间对幸福感的影响仍具有统计学意义（d=0.72）。干预组内对幸福感和个人康复的影响持续到 12 个月随访。生存分析显示复发时间无显著差异。
本研究评估的多成分 PPI 可有效改善缓解期 BD 患者的心理健康和个人康复，因此是目前治疗缓解期 BD 患者的有效补充。该研究以实用随机对照试验的形式进行，证明了该干预措施可以在现实临床环境中应用。
