Rogic Ivan, Huic Drazen
Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Croatia, Croatia.
School of Medicine, University of Zagreb, Croatia.
Nucl Med Rev Cent East Eur. 2023;26(0):49-51. doi: 10.5603/NMR.2023.0007.
Brown tumours are rare bone lesions occurring in patients with severe hyperparathyroidism (HPT) because of increased osteoclastic activity due to high levels of parathyroid hormone (PTH). We report the case of 30-year-old woman with secondary hyperparathyroidism due to severe chronic kidney diseases who underwent [18F]F-choline PET/CT scan for localization of the hyperfunctioning parathyroid gland before surgical treatment. [18F]F-choline PET/CT scan showed increased choline uptake in the lower left parathyroid gland and in multiple bone lytic lesions. Multiple focal choline uptake in bone corresponded to brown tumours - fibrous osteitis cystica.
棕色瘤是发生于严重甲状旁腺功能亢进（HPT）患者的罕见骨病变，其由于甲状旁腺激素（PTH）水平升高导致破骨细胞活性增加。我们报告了一名30岁因严重慢性肾脏疾病继发甲状旁腺功能亢进的女性病例，该患者在手术治疗前接受了[18F]F-胆碱PET/CT扫描以定位功能亢进的甲状旁腺。[18F]F-胆碱PET/CT扫描显示左下甲状旁腺及多个骨溶解性病变处胆碱摄取增加。骨内多个局灶性胆碱摄取对应于棕色瘤——囊性纤维性骨炎。
