多粘菌素耐药铜绿假单胞菌生物膜中，多粘菌素增强利福平的抗菌作用。
Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms.
机构信息
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Laboratory of Molecular Microbiology & Antimicrobials, Department of Pathology & Experimental Therapeutics, Medical School and IDIBELL, University of Barcelona, Hospitalet de Llobregat, Spain.
出版信息
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0164122. doi: 10.1128/aac.01641-22. Epub 2023 Mar 1.
Abstract
The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.
摘要
耐多药铜绿假单胞菌感染的出现促使人们需要寻找新的策略，例如使用抗生素联合治疗。在这些策略中，已经研究了多粘菌素与其他抗生素的联合使用。在这里，研究了多粘菌素和利福平联合应用对多粘菌素耐药铜绿假单胞菌浮游和静止细胞的作用。形成动态生物膜并对其进行处理，导致生物膜中既对多粘菌素耐药又对多粘菌素敏感的铜绿假单胞菌产生积极的杀伤作用。结果表明，多粘菌素对外膜的作用促进了利福平的渗透，而与多粘菌素耐药表型无关。基于这些数据，我们提出将多粘菌素-利福平联合治疗作为治疗多粘菌素耐药铜绿假单胞菌感染的一种有前途的方法。
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