Zheng Hong-Yu, Wang Yan-Xia, Zhou Kun, Xie Hai-Lin, Ren Zhong, Liu Hui-Ting, Ou Yang-Shao, Zhou Zhi-Xiang, Jiang Zhi-Sheng
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, 421001, China.
J Cell Commun Signal. 2023 Sep;17(3):495-506. doi: 10.1007/s12079-023-00730-5. Epub 2023 Mar 1.
CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.
CREB调节转录共激活因子2（CRTC2或TORC2）是CREB（环磷酸腺苷反应元件结合蛋白）的转录共激活因子，其通过环磷酸腺苷途径、哺乳动物雷帕霉素靶蛋白（mTOR）途径、固醇调节元件结合蛋白1（SREBP1）、固醇调节元件结合蛋白2（SREBP2）等物质影响人体能量代谢。目前关于CRTC2的研究主要集中在葡萄糖和脂质代谢方面，相关研究表明，CRTC2可通过影响代谢稳态参与相关疾病的发生发展。研究发现，Crtc2在多种细胞类型中作为环磷酸腺苷和Ca2+信号通路的信号调节剂，Ser171和Ser275位点的磷酸化可通过控制CRTC2在细胞质和细胞核之间穿梭来调节下游生物学功能。
