Ysbyty Cwm Rhondda Hospital, Cwm Taf Morgannwg University Health Board, Tonypandy, CF40 2LX, Wales, UK.
Int Ophthalmol. 2023 Aug;43(8):2633-2641. doi: 10.1007/s10792-023-02662-w. Epub 2023 Mar 1.
Relapsing polychondritis (RPC) is a rare, multi-system, inflammatory disorder. Ocular disease is estimated to occur in 14-67% of patients with RPC, and any ocular structure can be affected. Published case reports and series of RPC were analysed to determine the frequency and nature of the ocular manifestations of RPC, including the age and gender distribution.
A literature search of the MEDLINE database for case reports and series on RPC was conducted in October 2021 using search terms [relapsing polychondritis (MeSH Major Topic)] OR [relapsing polychondritis (Title/Abstract)]. Articles were included if the diagnosis of RPC was confirmed using established diagnostic criteria and if the paper described the clinical features of patients with RPC.
546 articles (454 case reports and 92 case series) described the clinical features in a total of 2414 patients with RPC. 49% of patients with RPC had ocular involvement, and this was a presenting feature in 21%. The most common ocular manifestations were scleritis (32%), episcleritis (31%) and uveitis (23%).
Many patients with RPC will be seen by an ophthalmologist during the course of their disease. Knowledge and awareness of RPC and its ocular manifestations is therefore essential to enable the ophthalmologist to make the diagnosis.
复发性多软骨炎（RPC）是一种罕见的多系统炎症性疾病。据估计，RPC 患者中有 14%-67%会出现眼部疾病，任何眼部结构都可能受到影响。分析已发表的 RPC 病例报告和系列研究，以确定 RPC 的眼部表现的频率和性质，包括年龄和性别分布。
2021 年 10 月，使用检索词[复发性多软骨炎（MeSH 主要主题）]或[复发性多软骨炎（标题/摘要）]，在 MEDLINE 数据库中对 RPC 的病例报告和系列研究进行文献检索。如果使用既定的诊断标准确诊 RPC，并且论文描述了 RPC 患者的临床特征，则纳入研究。
共 546 篇文章（454 篇病例报告和 92 篇病例系列）描述了 2414 例 RPC 患者的临床特征。49%的 RPC 患者存在眼部受累，21%的患者以眼部表现为首发症状。最常见的眼部表现为巩膜炎（32%）、表层巩膜炎（31%）和葡萄膜炎（23%）。
在疾病过程中，许多 RPC 患者会就诊于眼科医生。因此，了解和认识 RPC 及其眼部表现对于眼科医生做出诊断至关重要。
