HIV 病毒血症导致可卡因使用者的神经认知障碍。
HIV viremia contributes to neurocognitive impairments in persons who use cocaine.
机构信息
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA.
College of Liberal and Professional Studies, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
J Neurovirol. 2023 Jun;29(3):331-336. doi: 10.1007/s13365-022-01100-4. Epub 2023 Mar 1.
Abstract
Persons with HIV (PWH) who use illicit drugs are at elevated risk for neurocognitive impairment (NCI). This study investigated the effects of HIV disease and HIV viremia on NCI among adults who use cocaine. PWH who were not virologically suppressed showed greater global deficits compared to participants with HIV viral suppression and HIV-negative participants, but no differences emerged between the latter two groups. These findings highlight the adverse effects of poorly controlled HIV disease on NCI, beyond the independent effects of cocaine on cognition, and underscore the importance of strengthening the HIV care continuum for persons who use cocaine.
摘要
HIV 感染者（PWH）如果使用非法药物，其神经认知障碍（NCI）的风险会增加。本研究调查了 HIV 疾病和 HIV 病毒血症对使用可卡因的成年人 NCI 的影响。未被病毒学抑制的 PWH 与 HIV 病毒抑制的参与者和 HIV 阴性参与者相比，表现出更严重的整体缺陷，但后两组之间没有差异。这些发现强调了 HIV 疾病控制不佳对 NCI 的不良影响，超过了可卡因对认知的独立影响，突出了加强对使用可卡因的人的 HIV 护理连续体的重要性。
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