Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China.
J Mater Chem B. 2023 Mar 22;11(12):2700-2705. doi: 10.1039/d2tb02295h.
The pursuit of phototheranostic agents with near-infrared II (NIR-II) emission, high photothermal conversion efficiency (PCE) and the robust generation of reactive oxygen species (ROS) in the aggregated state is always in high demand but remains a big challenge. Herein, we report a simple strategy to endow molecules with NIR-II imaging and photothermal therapy (PTT)/photodynamic therapy (PDT) abilities by equipping NIR-II aggregation-induced emission luminogens (AIEgens) with the cationic trimethylammonium unit, named as TDTN. The resultant TDTN species can self-assemble into nanoparticles, which exhibit a maximum emission at ∼1052 nm, a high PCE (66.7%), type I and type II ROS generation and a mitochondria-targeting ability, simultaneously. The TDTN can realize brain imaging with bright fluorescence and an effective tumor killing effect. Overall, this work presents an innovative design strategy to develop multimodality phototheranostic agents.
我们报告了一种简单的策略，通过在近红外 II（NIR-II）聚集诱导发射发光体（AIEgen）上配备阳离子三甲铵单元，赋予分子 NIR-II 成像以及光热治疗（PTT）/光动力治疗（PDT）能力，该策略被命名为 TDTN。所得的 TDTN 物种可以自组装成纳米颗粒，其在约 1052nm 处表现出最大发射，同时具有高的光热转换效率（66.7%）、I 型和 II 型 ROS 的生成以及靶向线粒体的能力。TDTN 可以实现具有明亮荧光的脑部成像和有效的肿瘤杀伤作用。总的来说，这项工作提出了一种创新的设计策略，用于开发多模式光热治疗剂。
