Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine.
Department of Internal Medicine, Matsunami General Hospital.
J Nutr Sci Vitaminol (Tokyo). 2023;69(1):46-52. doi: 10.3177/jnsv.69.46.
We investigated the associations of plasma 25-hydroxy vitamin D (25(OH)D) concentration and the dietary intake of vitamin D with insulin resistance in Japanese women. Study participants were 406 Japanese women attended a health examination. They were not taking hormones or medications for diabetes and had no history of cancer, ischemic heart disease, or stroke. Information regarding medical history and lifestyle factors was obtained by a self-administered questionnaire, while hours of sun exposure were determined through interviews. Dietary intake of vitamin D was evaluated using a validated food frequency questionnaire. Fasting plasma glucose and insulin concentrations were measured, and insulin resistance (HOMA-IR) scores were calculated based on homeostasis model assessment. Women with vitamin D deficiency (25(OH)D<20 ng/mL) had significantly higher fasting plasma insulin concentration and HOMA-IR than did the other women. Plasma 25(OH)D concentration was significantly and inversely associated with fasting plasma insulin level and HOMA-IR after controlling for age, season, menopausal status, BMI, smoking status, alcohol intake, physical exercise, and intakes of fat and calcium. Dietary vitamin D intake was not associated with HOMA-IR concentration after adjusting for these covariates and hours of sun exposure. Although significant inverse association between plasma 25(OH)D concentration and HOMA-IR was observed in women with a low BMI, low fat intake, or a high calcium intake, the interaction terms were not statistically significant. Data suggest that plasma vitamin D, but not dietary vitamin D, is inversely associated with fasting plasma insulin concentration and HOMA-IR in non-diabetic Japanese women.
我们研究了血浆 25-羟维生素 D（25（OH）D）浓度和维生素 D 饮食摄入量与日本女性胰岛素抵抗之间的关系。研究参与者为 406 名参加健康检查的日本女性。她们没有服用治疗糖尿病的激素或药物，也没有癌症、缺血性心脏病或中风病史。通过自我管理问卷获得有关病史和生活方式因素的信息，而通过访谈确定暴露于阳光的时间。使用经过验证的食物频率问卷评估维生素 D 的饮食摄入量。测量空腹血糖和胰岛素浓度，并根据稳态模型评估计算胰岛素抵抗（HOMA-IR）评分。维生素 D 缺乏症（25（OH）D<20ng/mL）的女性空腹胰岛素浓度和 HOMA-IR 明显高于其他女性。在校正年龄、季节、绝经状态、BMI、吸烟状况、酒精摄入、体育锻炼以及脂肪和钙摄入量后，血浆 25（OH）D 浓度与空腹血浆胰岛素水平和 HOMA-IR 呈显著负相关。在调整这些协变量和暴露于阳光的时间后，饮食维生素 D 摄入量与 HOMA-IR 浓度无关。尽管在 BMI 低、脂肪摄入量低或钙摄入量高的女性中观察到血浆 25（OH）D 浓度与 HOMA-IR 之间存在显著的负相关，但交互项没有统计学意义。数据表明，在非糖尿病的日本女性中，血浆维生素 D，而不是饮食维生素 D，与空腹胰岛素浓度和 HOMA-IR 呈负相关。
