成功治疗血友病 A 患儿合并过敏性紫癜便血 1 例报告
Successful treatment of Henoch-Schönlein purpura-associated hematochezia in a child with hemophilia A: a case report.
机构信息
Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medicine University, National Center for Children's Health, No.56 Nanlishi Road, Beijing, 100045, China.
出版信息
BMC Pediatr. 2023 Mar 2;23(1):98. doi: 10.1186/s12887-023-03874-w.
BACKGROUND
Henoch-Schönlein purpura (HSP) is a common form of immunological vasculitis in children. Hemophilia A is a genetic disorder and characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII deficiency. Both diseases increase the risk of bleeding, but they have different mechanisms. How should we treat patients with both diseases?
CASE PRESENTATION
An 8-year-old male with hemophilia A was diagnosed with HSP while receiving coagulation factor VIII replacement therapy in our hospital. Hematochezia occurred 6 days after the diagnosis of HSP. And he treated with coagulation FVIII, methylprednisolone and hemostatic drugs.
CONCLUSIONS
There is no causal relationship between hemophilia A and HSP, but both diseases can cause bleeding. This child's hematochezia was caused by HSP, but hemophilia could not be ignored during the treatment. Our case report adds to the present body of knowledge about the treatment of HSP associated hematochezia in a child with hemophilia A.
背景
过敏性紫癜（HSP）是儿童常见的免疫性血管炎。甲型血友病是一种遗传性疾病，其特征是由于因子 VIII 缺乏而导致自发性出血或出血时间延长。这两种疾病都会增加出血的风险，但它们的发病机制不同。对于同时患有这两种疾病的患者，我们应该如何治疗？
病例介绍
一名 8 岁男性血友病 A 患儿在我院接受凝血因子 VIII 替代治疗时被诊断为 HSP。HSP 确诊后第 6 天出现血便。他接受了凝血因子 FVIII、甲泼尼龙和止血药物治疗。
结论
甲型血友病与 HSP 之间没有因果关系，但这两种疾病都可导致出血。该患儿的血便是由 HSP 引起的，但在治疗过程中不能忽视血友病。我们的病例报告增加了目前关于血友病 A 儿童 HSP 相关血便治疗的知识。
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