Ibet Marie Y Sih, Erickson F Torio, Maurice V Bayhon, Jonna Mae D Maala, Manuel M Mariano, Rhoderick M Casis, Carlo G Barredo, Juan Manuel L Mariano, Jo-Celine M Leong, Charlene Mary C Mercado, Jan Rehino M Yanto, Juan Martin J Magsanoc, Angela P Camacho, Miriam Joy C Calaguas, Thomas Vincent T Vergara, Julius Cezar P Rojales, Kathleen Jane U Cortez, Ma Socorro S D Santos, Roy G Torcuator
Section of Neurosurgery, Institute for Neurosciences, St. Luke's Medical Center Quezon City and Global City, Philippines.
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Radiosurg SBRT. 2022;8(3):175-180.
Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine.
This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team.
A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64, = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ (5, N = 51) = 11.11 ( = 0.049)].
The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.
立体定向放射外科（SRS）是癌症患者多模态治疗的一部分。本研究的目的是确定影响接受SRS治疗脊柱转移性肿瘤的菲律宾患者总生存期（OS）的因素。
这是一项对在单一机构接受脊柱SRS治疗转移性肿瘤的菲律宾患者队列的回顾性分析。由该机构的脊柱SRS团队确定潜在预测因素并在队列中进行描述。使用Cox比例风险回归模型基于该机构脊柱SRS团队确定的预测因素构建模型。
我们机构共有51例连续患者的68处脊柱转移灶接受了SRS治疗。中位总生存期为13.1个月（95%置信区间为7.1至19.1）。多因素分析显示，与总生存期相关的显著预测因素为内脏肿瘤起源（调整后风险比：3.08，95%置信区间为1.24至7.64，P = 0.015）和心血管疾病（调整后风险比：2.50，95%置信区间为1.04至5.94，P = 0.039），剂量和分次次数作为协变量[模型Wald χ(5, N = 51) = 11.11（P = 0.049）]。
内脏肿瘤起源和心血管疾病的存在是与接受SRS治疗的脊柱转移菲律宾患者较低总生存期相关的独立因素。
