Cargile M, Neyman S L, Hebeler R F, Askins R, O'Leary J P
Department of Surgery, Baylor University Medical Center, Dallas, Tex. 75246.
South Med J. 1987 Nov;80(11):1355-9. doi: 10.1097/00007611-198711000-00006.
We evaluated the effect of a selective thromboxane synthetase inhibitor (TSI) on the patency of autogenous vein grafts in dogs. Treatment involved oral dosing (10 mg/kg bid) of TSI or placebo, combined with local treatment of the graft with TSI or placebo (papavarine) at the time of implantation. At harvest, two animals, one from each oral dosing group, had an occluded graft; both grafts had been locally treated with papavarine. We found no significant histopathologic difference between graft treatment groups. Attempts to estimate the effect of TSI dosing on the prostacyclin/thromboxane balance through radioimmunoassay analysis of graft perfusates were unsuccessful. As measured by in vitro platelet aggregation, oral TSI was found to alter platelet function, though not in a dose-dependent fashion, and the animals rebounded toward normal at 12 hours.
我们评估了一种选择性血栓素合成酶抑制剂（TSI）对犬自体静脉移植物通畅性的影响。治疗方法包括口服TSI（10mg/kg，每日两次）或安慰剂，同时在植入时用TSI或安慰剂（罂粟碱）对移植物进行局部处理。在取材时，每组口服给药组各有一只动物的移植物发生闭塞；两只移植物均接受了罂粟碱局部处理。我们发现移植物治疗组之间在组织病理学上无显著差异。通过对移植物灌注液进行放射免疫分析来评估TSI给药对前列环素/血栓素平衡的影响的尝试未成功。通过体外血小板聚集测定发现，口服TSI可改变血小板功能，但其并非呈剂量依赖性，并且动物在12小时后恢复至正常状态。
