Türkkan Sinan, Yılmaz Emre, Bindal Mustafa, Çelik Başaran Fatmanur, Şahin Mehmet Furkan, Beyoğlu Muhammet Ali, Yazıcıoğlu Alkın, Yekeler Erdal
University of Health Sciences Turkey, Ankara City Hospital, Department of Thoracic Surgery and Lung Transplantation.
University of Health Sciences Turkey, Ankara City Hospital, Department of Anesthesiology and Reanimation.
Eurasian J Med. 2023 Feb;55(1):69-73. doi: 10.5152/eurasianjmed.2023.23007.
The transplantation waiting list is getting longer day by day with the spread of lung transplantation and awareness of it. However, the donor pool cannot keep up with this rate. Therefore, nonstandard (marginal) donors are widely used. By studying the lung donors presented at our center, we aimed to raise awareness of the donor shortage and compare clinical outcomes in recipients with standard and marginal donors.
The data from recipients and donors of lung transplants performed at our center between March 2013 and November 2022 were retrospectively reviewed and recorded. Transplants with ideal and standard donors were classified as group 1, and those with marginal donors were classified as group 2. Primary graft dysfunction rates, intensive care unit, and hospital stay days were compared.
Eighty-nine lung transplants were performed. A total of 46 recipients were in group 1 and 43 were in group 2. There were no differences between groups in the development of stage 3 primary graft dysfunction. However, a significant difference was found in the marginal group for developing any stage primary graft dysfunction. Donors were mostly from the western and southern regions of the country and from the education and research hospitals.
Because of the donor shortage in lung transplantation, transplant teams tend to use marginal donors. Stimulating and supportive education for healthcare professionals to recognize brain death and public education to raise awareness about organ donation are necessary to spread organ donation throughout the country. Although our results using marginal donors are similar with the standard group, each recipient and donor should be assessed individually.
随着肺移植的普及及其认知度的提高，移植等待名单日益延长。然而，供体库无法跟上这一速度。因此，非标准（边缘）供体被广泛使用。通过研究我院出现的肺供体，我们旨在提高对供体短缺的认识，并比较接受标准供体和边缘供体的受者的临床结局。
回顾性分析并记录了2013年3月至2022年11月在我院进行的肺移植受者和供者的数据。将使用理想和标准供体的移植归为第1组，使用边缘供体的移植归为第2组。比较原发性移植物功能障碍发生率、重症监护病房住院时间和住院天数。
共进行了89例肺移植。第1组有46例受者，第2组有43例受者。两组在3期原发性移植物功能障碍的发生方面无差异。然而，在边缘供体组中，任何阶段原发性移植物功能障碍的发生存在显著差异。供体大多来自该国西部和南部地区以及教育和研究医院。
由于肺移植供体短缺，移植团队倾向于使用边缘供体。为医疗保健专业人员开展关于识别脑死亡的激励性和支持性教育以及开展公众教育以提高器官捐赠意识，对于在全国范围内推广器官捐赠是必要的。虽然我们使用边缘供体的结果与标准组相似，但每个受者和供体都应进行单独评估。
