Surgery Department, Hospital Clínico Universitario "Virgen de la Arrixaca", School of Medicine, University of Murcia, Campus de Ciencias de la Salud. Edificio Departamental, Office 4.27, 30120, Murcia, Spain.
Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
Arch Dermatol Res. 2023 Sep;315(7):1971-1978. doi: 10.1007/s00403-023-02571-z. Epub 2023 Mar 2.
The anatomical location of cutaneous melanoma is a relevant independent prognostic factor in melanoma. The aim of the study is to know the prognosis of lower limb cutaneous melanoma related to their location within the limb, regardless of the histological type, and if there are any other influencing variables. A real-world data observational study was developed. The lesions were divided depending on the location of the melanoma (thigh, leg and foot). Bivariate and multivariate analysis were performed, and melanoma-specific survival and disease-free survival rates were calculated. When these analysis were done, the results showed that, in melanomas of the lower limb, location on the foot presented a lower melanoma-specific survival rate compared to more proximal locations, and only the anatomical location presents statistical significance to discriminate cases with a higher mortality risk and a lower disease-free survival rate among distal melanomas (mainly on the foot). In conclusion, this study confirms that a more distal location of lower limb cutaneous melanoma is a relevant prognostic factor.Trial registration number NCT04625491 retrospectively registered.
皮肤黑色素瘤的解剖位置是黑色素瘤的一个相关独立预后因素。本研究旨在了解下肢皮肤黑色素瘤的预后与其在肢体中的位置的关系，而不考虑组织学类型，以及是否存在任何其他影响因素。进行了一项真实世界数据的观察性研究。根据黑色素瘤的位置（大腿、小腿和足部）对病变进行了划分。进行了双变量和多变量分析，并计算了黑色素瘤特异性生存率和无病生存率。当进行这些分析时，结果表明，在下肢黑色素瘤中，足部的黑色素瘤特异性生存率低于更靠近近端的位置，只有解剖位置具有统计学意义，可以区分远端黑色素瘤（主要在足部）中死亡率更高和无病生存率更低的病例。总之，本研究证实下肢皮肤黑色素瘤的位置更靠远端是一个重要的预后因素。试验注册号：NCT04625491 为回顾性注册。
