Verdolini Norma, Moreno-Ortega Marta, Salgado-Pineda Pilar, Monté Gemma, de Aragón Ana Martínez, Dompablo Mónica, McKenna Peter J, Salvador Raymond, Palomo Tomás, Pomarol-Clotet Edith, Rodriguez-Jimenez Roberto
FIDMAG Germanes Hospitalàries Research Foundation, c/Dr. Pujades 38, 08830, Sant Boi de Llobregat, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st, 12-0, 08036 Barcelona, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain.
CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute/Columbia University Medical Center, New York, USA.
J Affect Disord. 2023 May 15;329:307-314. doi: 10.1016/j.jad.2023.02.132. Epub 2023 Feb 28.
Few studies have examined the functional brain correlates of the performance of the Stroop task in bipolar disorder (BD). It is also not known whether it is associated with failure of de-activation in the default mode network, as has been found in studies using other tasks.
Twenty-four BD patients and 48 age, sex and educationally estimated intellectual quotient (IQ) matched healthy subjects (HS) underwent a functional MRI during performance of the counting Stroop task. Task-related activations (incongruent versus congruent condition) and de-activations (incongruent versus fixation) were examined using whole-brain, voxel-based methodology.
Both the BD patients and the HS showed activation in a cluster encompassing the left dorsolateral and ventrolateral prefrontal cortex and the rostral anterior cingulate cortex and supplementary motor area, with no differences between them. The BD patients, however, showed significant failure of de-activation in the medial frontal cortex and the posterior cingulate cortex/precuneus.
The failure to find activation differences between BD patients and controls suggests that the 'regulative' component of cognitive control remains intact in the disorder, at least outside episodes of illness. The failure of de-activation found adds to evidence documenting trait-like default mode network dysfunction in the disorder.
很少有研究探讨双相情感障碍（BD）患者在执行斯特鲁普任务时大脑的功能相关性。也不清楚它是否与默认模式网络去激活失败有关，正如在使用其他任务的研究中所发现的那样。
24名双相情感障碍患者和48名年龄、性别及教育程度匹配的智商（IQ）相当的健康受试者（HS）在执行计数斯特鲁普任务期间接受了功能磁共振成像检查。使用基于体素的全脑方法检查任务相关激活（不一致与一致条件）和去激活（不一致与注视）情况。
双相情感障碍患者和健康受试者在包括左侧背外侧和腹外侧前额叶皮层、喙部前扣带回皮层及辅助运动区的一个簇中均显示激活，两者之间无差异。然而，双相情感障碍患者在内侧前额叶皮层和后扣带回皮层/楔前叶显示出明显的去激活失败。
在双相情感障碍患者和对照组之间未发现激活差异，这表明认知控制的“调节”成分在该疾病中保持完整，至少在疾病发作之外是这样。发现的去激活失败进一步证明了该疾病中存在类似特质的默认模式网络功能障碍。
