Yuste Berenguer E, Colomina Morales J, Señor Revuelto P, Drudis Morell R, Torra Riera M, Pilares Ortega E P, Trujillano Cabello J
Servicio de COT, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
Servicio de COT, Hospital Universitari de Santa Maria, Lleida, Spain.
Rev Esp Cir Ortop Traumatol. 2023 Jul-Aug;67(4):T309-T316. doi: 10.1016/j.recot.2023.02.017. Epub 2023 Mar 1.
Detection and decolonization of Staphylococcus aureus prior to surgery is postulated as an option to reduce the risk of infection in arthroplasties. The aim of this study was to evaluate the effectiveness of a screening programme for S. aureus in total knee arthroplasty (TKA) and total hip arthroplasty (THA), the incidence of infection with respect to a historical cohort, and its economic viability.
Pre-post intervention study in patients undergoing primary knee and hip prostheses in 2021, a protocol was carried out to detect nasal colonization by S. aureus and eradication if appropriate, with intranasal mupirocin, post-treatment culture with results three weeks between post-treatment culture and surgery. Efficacy measures are evaluated, costs are analyzed and the incidence of infection is compared with respect to a historical series of patients operated on between January and December 2019, performing a descriptive and comparative statistical analysis.
The groups were statistically comparable. Culture was performed in 89%, with 19 (13%) positive patients. Treatment was confirmed in 18, control culture in 14, all decolonized; none suffered infection. One culture-negative patient suffered from Staphylococcus epidermidis infection. In historical cohort: three suffered deep infection by S. epidermidis, Enterobacter cloacae, Staphylococcus aureus. The cost of the programme is €1661.85.
The screening programme detected 89% of the patients. The prevalence of infection in the intervention group was lower than in the cohort, with S. epidermidis being the main micro-organism, different from S. aureus described in the literature and in the cohort. We believe that this programme is economically viable, as its costs are low and affordable.
术前检测和清除金黄色葡萄球菌被认为是降低关节置换术感染风险的一种选择。本研究的目的是评估全膝关节置换术(TKA)和全髋关节置换术(THA)中金黄色葡萄球菌筛查计划的有效性、相对于历史队列的感染发生率及其经济可行性。
对2021年接受初次膝关节和髋关节假体置换的患者进行干预前后研究,执行一项方案以检测金黄色葡萄球菌的鼻腔定植情况,若有必要则使用鼻内莫匹罗星进行清除,治疗后培养,治疗后培养与手术之间间隔三周得出结果。评估疗效指标,分析成本,并将感染发生率与2019年1月至12月期间接受手术的历史患者系列进行比较,进行描述性和比较性统计分析。
各组在统计学上具有可比性。89%的患者进行了培养,其中19例(13%)呈阳性。18例患者得到确诊治疗,14例进行了对照培养,所有患者均已清除定植;无一例感染。一名培养结果为阴性的患者发生了表皮葡萄球菌感染。在历史队列中:3例患者分别发生了表皮葡萄球菌、阴沟肠杆菌、金黄色葡萄球菌引起的深部感染。该计划的成本为1661.85欧元。
筛查计划检测出了89%的患者。干预组的感染患病率低于队列,主要微生物为表皮葡萄球菌,与文献及队列中描述的金黄色葡萄球菌不同。我们认为该计划在经济上是可行的,因为其成本低廉且可承受。