2 型糖尿病发病机制中的 DNA 甲基化。

DNA methylation in the pathogenesis of type 2 diabetes.

机构信息

Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.

Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.

出版信息

Vitam Horm. 2023;122:147-169. doi: 10.1016/bs.vh.2022.11.002. Epub 2022 Dec 16.

DOI:10.1016/bs.vh.2022.11.002

PMID:36863792

Abstract

Type 2 diabetes (T2D) is a metabolic disease characterized by the development of β-cell dysfunction with hepatic, muscular and adipose tissue insulin resistance. Although the molecular mechanisms leading to its development are not entirely known, investigations of its causes reveal a multifactorial contribution to its development and progression in most cases. In addition, regulatory interactions mediated by epigenetic modifications such as DNA methylation, histone tail modifications and regulatory RNAs have been found to play a significant role in the etiology of T2D. In this chapter, we discuss the role of DNA methylation and its dynamics in the development of the pathological features of T2D.

摘要

2 型糖尿病（T2D）是一种代谢疾病，其特征是β细胞功能障碍，伴有肝、肌肉和脂肪组织胰岛素抵抗。尽管导致其发展的分子机制尚不完全清楚，但对其病因的研究表明，在大多数情况下，其发展和进展是多种因素共同作用的结果。此外，研究发现，DNA 甲基化、组蛋白尾部修饰和调节 RNA 等表观遗传修饰介导的调节相互作用在 T2D 的发病机制中发挥着重要作用。在本章中，我们讨论了 DNA 甲基化及其动态变化在 T2D 病理特征发展中的作用。