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Identification of the c-Jun/H19/miR-19/JNK1 cascade during hepatic stellate cell activation.

作者信息

Sun Ying, Liu Chunyu, Guo Xu, Zhao Jiayu, Xiao Anqi, Yin Kai, Liu Ming, Sun Xinlei, Chen Xi, Liu Minghui

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.

出版信息

Clin Transl Med. 2023 Mar;13(3):e1106. doi: 10.1002/ctm2.1106.

DOI:10.1002/ctm2.1106
PMID:36864707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9982076/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/f7a9eca67769/CTM2-13-e1106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/1c92e569f4c2/CTM2-13-e1106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/63fbd058a4b9/CTM2-13-e1106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/7f9b9b761d81/CTM2-13-e1106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/f7a9eca67769/CTM2-13-e1106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/1c92e569f4c2/CTM2-13-e1106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/63fbd058a4b9/CTM2-13-e1106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/7f9b9b761d81/CTM2-13-e1106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1997/9982076/f7a9eca67769/CTM2-13-e1106-g002.jpg

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Identification of the c-Jun/H19/miR-19/JNK1 cascade during hepatic stellate cell activation.肝星状细胞激活过程中c-Jun/H19/miR-19/JNK1级联反应的鉴定
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本文引用的文献

1
Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis.胆管细胞来源的外泌体长链非编码 RNA H19 促进肝星状细胞激活和胆汁淤积性肝纤维化。
Hepatology. 2019 Oct;70(4):1317-1335. doi: 10.1002/hep.30662. Epub 2019 May 24.
2
Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans.胆管细胞来源的外泌体长非编码 RNA H19 促进小鼠和人类胆汁淤积性肝损伤。
Hepatology. 2018 Aug;68(2):599-615. doi: 10.1002/hep.29838. Epub 2018 May 2.
3
Hepatic stellate cells as key target in liver fibrosis.
肝星状细胞作为肝纤维化的关键靶点。
Adv Drug Deliv Rev. 2017 Nov 1;121:27-42. doi: 10.1016/j.addr.2017.05.007. Epub 2017 May 12.
4
Mechanisms of hepatic stellate cell activation.肝星状细胞激活的机制。
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411. doi: 10.1038/nrgastro.2017.38. Epub 2017 May 10.
5
H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule.H19 通过阻止 ZEB1 介导的上皮细胞粘附分子抑制来促进胆汁淤积性肝纤维化。
Hepatology. 2017 Oct;66(4):1183-1196. doi: 10.1002/hep.29209. Epub 2017 Aug 26.
6
The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice.长链非编码RNA H19在多药耐药2基因敲除小鼠胆汁淤积性肝损伤性别差异中的作用
Hepatology. 2017 Sep;66(3):869-884. doi: 10.1002/hep.29145. Epub 2017 Jul 20.
7
Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis.Jnk1 在小鼠肝星状细胞中是肝纤维化的关键介质。
Gut. 2014 Jul;63(7):1159-72. doi: 10.1136/gutjnl-2013-305507. Epub 2013 Sep 13.
8
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.充满 JNK 的肝脏：细胞功能调控和疾病发病机制中的信号转导，以及临床方法。
Gastroenterology. 2012 Aug;143(2):307-20. doi: 10.1053/j.gastro.2012.06.004. Epub 2012 Jun 13.
9
Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis.miR-19b 对肝星状细胞介导的肝纤维化形成的抑制作用。
Hepatology. 2012 Jul;56(1):300-10. doi: 10.1002/hep.25613. Epub 2012 Jun 18.
10
Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition.抑制 c-Jun-N 末端激酶对肝纤维化的调节作用。
Gastroenterology. 2010 Jan;138(1):347-59. doi: 10.1053/j.gastro.2009.09.015. Epub 2009 Sep 24.