Travis C C
Health and Safety Research Division, Oak Ridge National Laboratory, Tennessee 37831.
Toxicology. 1987 Dec 1;47(1-2):3-13. doi: 10.1016/0300-483x(87)90157-0.
Quantitative risk assessment for carcinogenic chemicals is usually based on data obtained in animal studies conducted at very high levels of exposure. A key issue in using such data is the extrapolation of results from animals to man. Recently, physiological pharmacokinetic models can also be used to aid in extrapolating extrapolations. The models can also be used to aid in extrapolating between routes of administration. Model results for inhalation and ingestion of tetrachloroethylene will be presented and compared to experimental data for rats and humans.
致癌化学物质的定量风险评估通常基于在非常高暴露水平下进行的动物研究中获得的数据。使用此类数据的一个关键问题是将动物研究结果外推至人类。最近，生理药代动力学模型也可用于辅助外推。这些模型还可用于辅助不同给药途径之间的外推。将展示四氯乙烯吸入和摄入的模型结果，并与大鼠和人类的实验数据进行比较。
