Johnson Mahlon D, Rogers Eli J, Khan Muhammad Waqas, McMullen Phillip D, Akkipeddi Sajal Medha K, Mattingly Thomas, Benesch Curtis G, Bender Matthew T
Departments of Pathology (MDJ, PDM), Neurology (EJR, MWK, SMKA, CGB), and Neurosurgery (TM, MTB), University of Rochester Medical Center, NY.
Neurol Clin Pract. 2023 Feb;13(1):e200129. doi: 10.1212/CPJ.0000000000200129. Epub 2023 Jan 19.
The objective of this study was to present the clinical, histopathologic, and radiographic findings of a unique case of intimal sarcoma (IS) embolus presenting as a large vessel occlusion causing an ischemic stroke without a detectable primary tumor site.
Extensive examinations, multimodal imaging, laboratory testing, and histopathologic analysis were used in evaluation.
We report the case of a patient who presented with acute embolic ischemic stroke and was found to have IS based on a histopathologic evaluation of his embolectomy specimen. Subsequent comprehensive imaging studies failed to detect a primary tumor site. Multidisciplinary interventions including a course of radiotherapy were performed. The patient died of recurrent multifocal strokes 92 days after diagnosis.
Meticulous histopathologic analysis should be conducted on cerebral embolectomy specimens. Histopathology may be useful in diagnosing IS.
本研究的目的是呈现一例独特的内膜肉瘤（IS）栓子病例的临床、组织病理学和影像学表现，该栓子表现为大血管闭塞，导致缺血性中风，且未检测到原发肿瘤部位。
采用广泛的检查、多模态成像、实验室检测和组织病理学分析进行评估。
我们报告了一例以急性栓塞性缺血性中风就诊的患者，根据其取栓术标本的组织病理学评估发现患有IS。随后的全面影像学检查未能检测到原发肿瘤部位。进行了包括一个疗程放疗在内的多学科干预。患者在诊断后92天死于复发性多灶性中风。
应对脑取栓术标本进行细致的组织病理学分析。组织病理学可能有助于诊断IS。
