外周烧伤后脑组织的病理变化。

Chen Jigang, Zhang Danfeng, Zhang Junhui, Wang Yanni

Department of Burn and Plastic Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Burns Trauma. 2023 Feb 6;11:tkac061. doi: 10.1093/burnst/tkac061. eCollection 2023.

Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes. In clinical settings, it was once believed that brain injuries were not major pathological processes after burn, at least in part due to the unavailability of specific clinical manifestations. Burn-related brain injuries have been studied for more than a century, but the underlying pathophysiology has not been completely clarified. This article reviews the pathological changes in the brain following peripheral burns at the anatomical, histological, cytological, molecular and cognitive levels. Therapeutic indications based on brain injury as well as future directions for research have been summarized and proposed.

脑损伤是热烧伤患者常见的并发症，且与不良预后相关。在临床环境中，人们曾一度认为脑损伤并非烧伤后的主要病理过程，至少部分原因是缺乏特异性临床表现。与烧伤相关的脑损伤已被研究了一个多世纪，但潜在的病理生理学机制尚未完全阐明。本文从解剖学、组织学、细胞学、分子学和认知水平等方面综述了外周烧伤后脑内的病理变化。总结并提出了基于脑损伤的治疗指征以及未来的研究方向。