Xu Dan, Lu Ming, Liu Ying, Chen Wansu, Yang Xiaole, Xu Min, Zhou Huifang, Wei Xiaoman, Zhu Yao, Song Qingxia
Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China.
Nanjing University of Chinese Medicine, Nanjing 210023, China.
Evid Based Complement Alternat Med. 2023 Feb 21;2023:6198001. doi: 10.1155/2023/6198001. eCollection 2023.
The aim of the present study is to investigate the rules and characteristics of the clinical administration of traditional Chinese medicine (TCM) in the treatment of polycystic ovary syndrome (PCOS) using data mining methods.
Medical cases of well-known contemporary TCM doctors treating PCOS were collected from the China National Knowledge Infrastructure, Chinese Biomedical Literature Service System, Wanfang, Chinese Scientific Journals Database, and PubMed; the data were then characterized, and a standardized database of medical cases was built. This database was used to (1) count the frequency of syndrome types and the herbs used in medical cases by data mining methods and (2) analyze drug association rules and systematic clustering methods.
A total of 330 papers were included, involving 382 patients and a total of 1,427 consultations. The most common syndrome type was kidney deficiency; sputum stasis was the core pathological product and causative factor. A total of 364 herbs were used. Among them, 22 herbs were used >300 times, including Danggui (), Tusizi (), Fuling (), Xiangfu (), and Baizhu (). Additionally, 22 binomial associations were obtained from the analysis of association rules; five clustering formulae were obtained via the analysis of high-frequency drug clusters; and 27 core combinations were obtained by k-means clustering of formula.
In the treatment of PCOS, TCM is primarily employed as a combination approach involving tonifying the kidneys, strengthening the spleen, eliminating damp and dissolving phlegm, activating blood circulation, and resolving blood stasis. The core prescription is primarily a compound intervention based on the Cangfu Daotan pill, Liuwei Dihuang pill, and Taohong Siwu decoction.
本研究旨在运用数据挖掘方法探讨中医治疗多囊卵巢综合征（PCOS）的临床用药规律及特点。
从中国知网、中国生物医学文献服务系统、万方、维普和PubMed收集当代知名中医治疗PCOS的医案；对数据进行特征提取，构建医案标准化数据库。利用该数据库：（1）通过数据挖掘方法统计医案中证型及用药频次；（2）分析药物关联规则及系统聚类方法。
共纳入330篇文献，涉及382例患者，共计1427诊次。最常见证型为肾虚；痰瘀是核心病理产物及致病因素。共使用364味中药。其中，22味中药使用频次>300次，包括当归、菟丝子、茯苓、香附、白术等。此外，通过关联规则分析得到22个二项式关联；通过高频药物聚类分析得到5个聚类方；通过方剂的k均值聚类得到27个核心组合。
中医治疗PCOS主要采用补肾、健脾、祛湿化痰、活血化瘀等综合方法。核心处方主要是以苍附导痰丸、六味地黄丸、桃红四物汤为基础的复合干预。
