Liu Huifang, Zhang KeLun, Jang Yoon Ok, Qiao Zhen, Jin Jie, Thi Dao Thuy Nguyen, Koo Bonhan, Park Chang Ook, Shin Yong
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
iScience. 2023 Jan 11;26(2):105922. doi: 10.1016/j.isci.2022.105922. eCollection 2023 Feb 17.
Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured extract (HI-AsE) and common agar-cultured extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis.
真菌会引发各种形式的侵袭性真菌病（IFD），并且真菌致敏会促使哮喘、哮喘严重程度以及其他超敏反应性疾病（如特应性皮炎（AD））的发展。在本研究中，我们引入了一种简便且可控的方法，即使用同双功能亚胺酯修饰的锌纳米纺锤体（HINS），来减弱真菌的菌丝生长，并减少真菌感染小鼠的超敏反应并发症。为了拓展对特异性和免疫机制的研究，我们使用HINS培养提取物（HI-AsE）和普通琼脂培养提取物（Con-AsE）作为精细的小鼠模型。安全浓度范围内的HINS复合材料不仅抑制了真菌的菌丝生长，还减少了真菌病原体的数量。通过对小鼠肺和皮肤组织的评估，在HI-AsE感染的小鼠中，哮喘发病机制（肺）和对侵袭性曲霉病的超敏反应（皮肤）最为轻微。因此，HINS复合材料减轻了哮喘以及对侵袭性曲霉病的超敏反应。
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