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生物启发的金属及金属氧化物纳米颗粒在生物医学科学中的潜力。

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences.

作者信息

Singh Kshitij Rb, Nayak Vanya, Singh Jay, Singh Ajaya Kumar, Singh Ravindra Pratap

机构信息

Department of Chemistry, Govt. V.Y.T. PG Autonomous College Durg Chhattisgarh (491001) India.

Department of Biotechnology, Faculty of Science, Indira Gandhi National Tribal University Amarkantak Madhya Pradesh (484886) India

出版信息

RSC Adv. 2021 Jul 15;11(40):24722-24746. doi: 10.1039/d1ra04273d. eCollection 2021 Jul 13.

Abstract

To date, various reports have shown that metallic gold bhasma at the nanoscale form was used as medicine as early as 2500 B.C. in India, China, and Egypt. Owing to their unique physicochemical, biological, and electronic properties, they have broad utilities in energy, environment, agriculture and more recently, the biomedical field. The biomedical domain has been used in drug delivery, imaging, diagnostics, therapeutics, and biosensing applications. In this review, we will discuss and highlight the increasing control over metal and metal oxide nanoparticle structures as smart nanomaterials utilized in the biomedical domain to advance the role of biosynthesized nanoparticles for improving human health through wide applications in the targeted drug delivery, controlled release drug delivery, wound dressing, tissue scaffolding, and medical implants. In addition, we have discussed concerns related to the role of these types of nanoparticles as an anti-viral agent by majorly highlighting the ways to combat the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, along with their prospects.

摘要

迄今为止,各种报告表明,早在公元前2500年,印度、中国和埃及就将纳米级形态的金属金药粉用作药物。由于其独特的物理化学、生物学和电子特性,它们在能源、环境、农业以及最近的生物医学领域都有广泛的用途。生物医学领域已将其用于药物递送、成像、诊断、治疗和生物传感应用。在这篇综述中,我们将讨论并强调对金属和金属氧化物纳米颗粒结构的控制日益增强,这些结构作为智能纳米材料应用于生物医学领域,以推动生物合成纳米颗粒在靶向药物递送、控释药物递送、伤口敷料、组织支架和医疗植入物等广泛应用中改善人类健康的作用。此外,我们还讨论了与这类纳米颗粒作为抗病毒剂的作用相关的问题,主要强调了对抗严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行的方法及其前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/905c/9036962/29708d05a1a2/d1ra04273d-f1.jpg

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