Wang Yiran, Li Qianru, Xue Xiao'ao, Xu Xiaoyun, Tao Weichu, Liu Sixu, Li Yunyi, Wang He, Hua Yinghui
Department of Sports Medicine, Fudan University, Shanghai, China.
School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Front Mol Neurosci. 2023 Feb 14;16:1096930. doi: 10.3389/fnmol.2023.1096930. eCollection 2023.
Pain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.
To investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.
A cross-database, cross-sectional study.
This study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.
The functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank ( = 0.005) and clinical validation dataset ( = 0.049), which was also significantly correlated with Tegner scores ( = 0.532, = 0.041) in patients with CAI.
A reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity.
疼痛在慢性踝关节不稳（CAI）中起重要作用，长期疼痛可能与踝关节功能障碍和异常神经可塑性有关。
研究健康对照者与CAI患者在疼痛相关脑区和踝关节运动相关脑区静息态功能连接的差异，并探讨患者运动功能与疼痛之间的关系。
跨数据库横断面研究。
本研究纳入了英国生物银行数据集，其中包括28例踝关节疼痛患者和109例健康对照者，以及一个验证数据集，其中包括15例CAI患者和15例健康对照者。所有参与者均接受静息态功能磁共振成像扫描，计算并比较两组之间疼痛相关脑区与踝关节运动相关脑区的功能连接（FC）。还探讨了CAI患者潜在不同功能连接与临床问卷之间的相关性。
在英国生物银行数据集（P = 0.005）和临床验证数据集中（P = 0.049），两组之间扣带回运动区与脑岛之间的功能连接均有显著差异，在CAI患者中，这也与Tegner评分显著相关（r = 0.532，P = 0.041）。
CAI患者扣带回运动区与脑岛之间的功能连接减少，这也与患者身体活动水平降低直接相关。
