Xu Juan, Yang Guang, An Wei, Wang Wei, Li Fangfang, Meng Yingtao, Wang Xingli
Department of Head and Neck Radiotherapy Ward 1, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Department of Nursing, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shangdong, China.
Head Neck. 2023 May;45(5):1122-1129. doi: 10.1002/hed.27313. Epub 2023 Mar 3.
This study aimed to investigate correlations of the severity of radiation-induced oral mucositis (RIOM) with epidermal growth factor (EGF) and inflammatory cytokines in patients with head and neck cancer (HNC).
Levels of inflammatory cytokines and EGF in saliva of HNC patients were measured. Correlations of inflammatory cytokines and EGF levels with RIOM severity and pain degree, and their diagnostic values on RIOM severity were determined.
Elevated IFN-γ, TNF-α, IL-2, and IL-6 levels, and reduced IL-4, IL-10, and EGF levels were found in patients with severe RIOM. IFN-γ, TNF-α, IL-2, and IL-6 were positively correlated with RIOM severity, while IL-10, IL-4, and EGF were negatively correlated with it. All factors were effective in predicting the severity of RIOM.
IFN-γ, TNF-α, IL-2, and IL-6 in saliva of patients with HNC are positively correlated with the severity of RIOM, and IL-4, IL-10, and EGF were negatively correlated with it.
本研究旨在探讨头颈部癌（HNC）患者放射性口腔黏膜炎（RIOM）的严重程度与表皮生长因子（EGF）及炎性细胞因子之间的相关性。
检测HNC患者唾液中炎性细胞因子和EGF的水平。确定炎性细胞因子和EGF水平与RIOM严重程度及疼痛程度的相关性，以及它们对RIOM严重程度的诊断价值。
重度RIOM患者的IFN-γ、TNF-α、IL-2和IL-6水平升高，IL-4、IL-10和EGF水平降低。IFN-γ、TNF-α、IL-2和IL-6与RIOM严重程度呈正相关，而IL-10、IL-4和EGF与RIOM严重程度呈负相关。所有因素在预测RIOM严重程度方面均有效。
HNC患者唾液中的IFN-γ、TNF-α、IL-2和IL-6与RIOM严重程度呈正相关，IL-4、IL-10和EGF与RIOM严重程度呈负相关。
