HIV血清阳性个体中血清α干扰素与超微结构标志物的关系。

The relationship of serum alpha-interferon and ultrastructural markers in HIV-seropositive individuals.

作者信息

Orenstein J M, Preble O T, Kind P, Schulof R

机构信息

George Washington University Medical Center, Washington, D.C. 20037.

出版信息

Ultrastruct Pathol. 1987;11(5-6):673-9. doi: 10.3109/01913128709048453.

DOI:10.3109/01913128709048453

PMID:3686706

Abstract

Two inclusions of the endoplasmic reticulum, tubuloreticular inclusion (TRI) and cylindrical confronting cisternae (CCC), are common to lymphocytes from individuals with AIDS and AIDS-related conditions. Both inclusions can be induced in vitro with alpha-interferon (IFN). IFN may also be elevated in both populations. Circulating lymphocytes containing TRI are seen prior to the appearance of serum IFN. CCC appear in circulating lymphocytes after TRI, and both regularly antedate the diagnosis of AIDS. As in systemic lupus erythematosus (SLE), it can be hypothesized that lymphocytes exposed locally to IFN acquire TRI and then appear in the peripheral blood to be followed subsequently by IFN. The data strongly suggest that the appearance of these markers may predict the progression to AIDS.

摘要

内质网的两种包涵体，即管网状包涵体（TRI）和柱状对置池（CCC），在患有艾滋病及艾滋病相关病症个体的淋巴细胞中很常见。这两种包涵体均可在体外由α干扰素（IFN）诱导产生。这两类人群体内的IFN水平也可能会升高。在血清IFN出现之前，就能见到含有TRI的循环淋巴细胞。CCC在TRI之后出现在循环淋巴细胞中，且二者通常都先于艾滋病的诊断出现。如同在系统性红斑狼疮（SLE）中一样，可以推测，局部暴露于IFN的淋巴细胞会获得TRI，然后出现在外周血中，随后出现IFN。数据有力地表明，这些标志物的出现可能预示着病情发展为艾滋病。