Kostianovsky M, Kang Y H, Grimley P M
Ultrastruct Pathol. 1983 Jun;4(4):331-6. doi: 10.3109/01913128309140585.
Tissue biopsies and peripheral blood samples from 10 patients with the characteristic clinical features of acquired immunodeficiency syndrome (AIDS) were examined by electron microscopy and ultracytochemical myeloperoxidase technique. Abundant tubuloreticular inclusions (TRI) were detected within the endoplasmic reticulum of capillary endothelial cells, histiocytes, and lymphocytes in kidneys, small bowel, and lymph nodes, and lymphocytes and monocytes from peripheral blood. In general, TRI were found in the same type of cells and with conspicuous high frequency in our cases of AIDS as had been previously described in systemic lupus erythematosus (SLE). These findings indicate a morphologic link between these immunological disorders and the presence of TRI, raising the possibility of similar pathogenetic mechanisms.
对10例具有获得性免疫缺陷综合征（AIDS）特征性临床症状的患者进行了组织活检和外周血样本检测，采用电子显微镜和超细胞化学髓过氧化物酶技术。在肾脏、小肠、淋巴结的毛细血管内皮细胞、组织细胞和淋巴细胞以及外周血的淋巴细胞和单核细胞的内质网内检测到大量管状网状包涵体（TRI）。总体而言，在我们的艾滋病病例中，TRI在相同类型的细胞中被发现，且频率显著高于先前系统性红斑狼疮（SLE）中所描述的情况。这些发现表明这些免疫紊乱与TRI的存在之间存在形态学联系，增加了类似致病机制的可能性。
