生物标志物：它们真的能指导我们的日常实践吗？

BIOMARKERS: CAN THEY REALLY GUIDE OUR DAILY PRACTICE?

作者信息

Tsangaris Iraklis, Antonakos Nikolaos, Fantoni Massimo, Kaplanski Gilles, Kyriazopoulou Evdoxia, Veas Francisco, Clemens Mark

机构信息

2nd Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Shock. 2023 Mar 1;59(3S Suppl 1):16-20. doi: 10.1097/SHK.0000000000001957. Epub 2022 Jul 24.

DOI:10.1097/SHK.0000000000001957

PMID:36867757

Abstract

Optimal management of septic patients requires accurate assessment of both current severity status and prognosis. Since the 1990s, substantial advances have been made in the use of circulating biomarkers for such assessments. This summary of the session on "Biomarkers: can they really use guide our daily practice?" presented at the 2021 WEB-CONFERENCE OF THE EUROPEAN SHOCK SOCIETY, 6 November 2021. These biomarkers include ultrasensitive detection of bacteremia, circulating soluble urokina-type plasminogen activator receptor (suPAR), C-reactive protein (CRP) and ferritin and procalcitonin. In addition, the potential application of novel multiwavelength optical biosensor technology allows noninvasive monitoring of multiple metabolites that can be used to assess severity and prognosis in septic patients. The application these biomarkers and improved technologies provide the potential for improved personalized management of septic patients.

摘要

脓毒症患者的最佳管理需要准确评估当前的严重程度和预后。自20世纪90年代以来，在使用循环生物标志物进行此类评估方面取得了重大进展。本文总结了2021年11月6日欧洲休克协会网络会议上题为“生物标志物：它们真的能指导我们的日常实践吗？”的会议内容。这些生物标志物包括菌血症的超敏检测、循环可溶性尿激酶型纤溶酶原激活剂受体（suPAR）、C反应蛋白（CRP）、铁蛋白和降钙素原。此外，新型多波长光学生物传感器技术的潜在应用允许对多种代谢物进行无创监测，这些代谢物可用于评估脓毒症患者的严重程度和预后。这些生物标志物和改进技术的应用为改善脓毒症患者的个性化管理提供了潜力。