Lekeux P, Art T
Laboratory for Cardiopulmonary Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.
Vet Rec. 1987 Oct 10;121(15):353-5. doi: 10.1136/vr.121.15.353.
The effects of necrotic laryngitis on the mechanics of breathing and gas exchange were investigated in five Belgian blue double muscled calves two to three months old. All the animals showed the typical clinical picture of the respiratory syndrome associated with naturally occurring necrotic laryngitis. Highly significant increases in total pulmonary resistance, minute viscous work of breathing and alveolar-arterial oxygen gradient, and highly significant decreases in dynamic lung compliance and arterial oxygen tension were recorded in the infected animals, when compared to reference values for healthy cattle. The ratio of inspiratory to expiratory viscous work of breathing was also significantly increased probably because of a partial collapse of the extrathoracic trachea during inspiration. It was concluded that necrotic laryngitis disturbs pulmonary function to such an extent that it impedes the growing process and predisposes the infected animals to secondary bronchopneumonia and ventilatory failure due to respiratory muscle fatigue.
在5头2至3月龄的比利时蓝双肌犊牛中，研究了坏死性喉炎对呼吸力学和气体交换的影响。所有动物均表现出与自然发生的坏死性喉炎相关的呼吸综合征典型临床症状。与健康牛的参考值相比，感染动物的总肺阻力、每分钟呼吸粘性功和肺泡 - 动脉氧梯度显著增加，动态肺顺应性和动脉血氧张力显著降低。吸气与呼气呼吸粘性功的比值也显著增加，这可能是由于吸气时胸外气管部分塌陷所致。得出的结论是，坏死性喉炎对肺功能的干扰程度足以阻碍生长过程，并使感染动物易患继发性支气管肺炎和因呼吸肌疲劳导致的通气衰竭。
