van Gerwen Maaike, Vasan Vikram, Genden Eric, Saul Shira R
Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Toxicology. 2023 Apr;488:153474. doi: 10.1016/j.tox.2023.153474. Epub 2023 Mar 2.
Thyroid cancer incidence has been steadily rising since the 1970s and exposure to environmental pollutants, including persistent organic pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxins, has emerged as a potential explanation for this increase. This study aimed to summarize available human studies on the association between TCDD exposure and thyroid cancer. A systematic review of the literature was performed searching the National Library of Medicine and National Institutes of Health PubMed, Embase, and Scopus databases, through January 2022, using the following keywords: "thyroid", "2,3,7,8-tetrachlorodibenzo-p-dioxin", "TCDD", "dioxin", and "Agent Orange". Six studies were included in this review. Three studies evaluated the acute exposure to the chemical factory accident in Seveso, Italy, and found a non-significant increase in the risk of thyroid cancer. Two studies investigating Agent Orange exposure among United States Vietnam War veterans found a significant risk of thyroid cancer following exposure. No association was found in one study evaluating TCDD exposure through herbicides. The current study highlights the limited information on the potential association between TCDD exposure and thyroid cancer and thus the need for future human studies, especially considering the persistent human exposure to dioxins in the environment.
自20世纪70年代以来，甲状腺癌的发病率一直在稳步上升，接触环境污染物，包括持久性有机污染物，如2,3,7,8-四氯二苯并对二恶英（TCDD）和其他二恶英，已成为这种增加的一个潜在解释。本研究旨在总结关于TCDD暴露与甲状腺癌之间关联的现有人类研究。通过检索美国国立医学图书馆和美国国立卫生研究院的PubMed、Embase和Scopus数据库，对截至2022年1月的文献进行了系统综述，使用了以下关键词：“甲状腺”、“2,3,7,8-四氯二苯并对二恶英”、“TCDD”、“二恶英”和“橙剂”。本综述纳入了六项研究。三项研究评估了意大利塞韦索化工厂事故中的急性暴露情况，发现甲状腺癌风险无显著增加。两项调查美国越战退伍军人接触橙剂情况的研究发现，接触后甲状腺癌风险显著增加。在一项评估通过除草剂接触TCDD的研究中未发现关联。当前研究强调了关于TCDD暴露与甲状腺癌之间潜在关联的信息有限，因此需要未来进行人类研究，特别是考虑到人类持续接触环境中的二恶英。
