Department of Internal Medicine, UPMC McKeesport, Pittsburgh, Pennsylvania, USA.
Department of Hospital Medicine, UPMC Mercy, Pittsburgh, Pennsylvania, USA.
Physiol Rep. 2023 Mar;11(5):e15617. doi: 10.14814/phy2.15617.
Cisplatin is a well-known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. We report a case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia. With recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium, he was diagnosed to have cisplatin induced renal salt wasting syndrome.
顺铂是一种众所周知的化疗药物，可导致低钠血症。它与多种肾脏疾病有关，包括肾小球滤过率降低的急性肾损伤、范可尼综合征和肾小管酸中毒、肾性尿崩症和肾性盐耗综合征。我们报告了一例老年男性表现为严重复发性低钠血症和肾前性氮质血症的病例。最近接触顺铂，同时存在显著的低血容量和钠尿丢失，诊断为顺铂引起的肾性盐耗综合征。
