Wang Xichen, Botchway Benson O A, Zhang Yong, Huang Min, Liu Xuehong
Department of Histology and Embryology, School of Medicine, Shaoxing University, Zhejiang, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China; Bupa Cromwell Hospital, London, UK.
Biomed Pharmacother. 2023 May;161:114466. doi: 10.1016/j.biopha.2023.114466. Epub 2023 Mar 2.
Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid, is a derivative of docosahexaenoic acid. It has showed beneficial effects in several animal models of central and peripheral nerve injuries. In this review, we summarize the anti-inflammatory, neuroprotective and pain hypersensitivity effects of maresin1 in nerve injury and provide a theoretical basis for the clinical treatment of nerve injury using maresin1.
神经损伤会破坏神经结构的完整性，从而显著影响人体的运动和感觉功能。神经损伤后，神经胶质细胞被激活，突触完整性遭到破坏，进而引发炎症和痛觉过敏。maresin1是一种ω-3脂肪酸，是二十二碳六烯酸的衍生物。它在多种中枢和外周神经损伤的动物模型中已显示出有益作用。在本综述中，我们总结了maresin1在神经损伤中的抗炎、神经保护和痛觉过敏作用，并为使用maresin1进行神经损伤的临床治疗提供理论依据。
