Nathan P W
The National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG Great Britain.
Pain. 1978 Dec;5(4):367-371. doi: 10.1016/0304-3959(78)90005-2.
Two trials of chlorprothixene were carried out, mainly on patients with moderate to severe post-herpetic neuralgia. When the drug was given as 50 mg b.d. to outpatients, unpleasant side-effects were more important than slight effects in alleviating pain. When the drug was given as 50 mg 6 hourly to inpatients for 5 days only, there was alleviation of constant chronic pain in a third of the patients; the effect is still lasting over a period of months in a few patients. The side-effects during the course of treatment are prominent. It is concluded that the drug is worth trying in the course recommended by Farber and Burks [1] when other means of controlling postherpetic neuralgia have failed. It would be best to give the course only to inpatients.
进行了两项关于氯丙硫蒽的试验，主要针对中度至重度带状疱疹后神经痛患者。当以每日两次、每次50毫克的剂量给予门诊患者时，不愉快的副作用比轻微的止痛效果更为明显。当仅以每6小时50毫克的剂量给予住院患者5天时，三分之一的患者持续性慢性疼痛得到缓解；少数患者的这种效果在几个月内仍然持续。治疗过程中的副作用较为突出。结论是，当其他控制带状疱疹后神经痛的方法失败时，该药物值得按照法伯和伯克斯[1]推荐的疗程进行尝试。最好仅对住院患者使用该疗程。
