Kirsten D, Meister W, Vattrodt W, Pielesch W, Seelig U, Hofmann I, Mönch D
Zentralklinik für Herz- und Lungenkrankheiten Bad Berka/DDR.
Z Erkr Atmungsorgane. 1987;169(2):109-16.
The study demonstrates the results of 203 patients with COLD in a follow-up of 4-6 years. The investigations include the clinical state, lung function tests, blood gas analyses and measurements of pulmonary arterial pressure (PAP). One hundred and six of these 203 patients were investigated 3 times within 4-6 years. Clinical state, oxygen partial pressure and airways' resistance showed the best correlation with the PAP at rest and under exercise. In 54 patients (= 51%) the pulmonary arterial pressure increased up to a pulmonary hypertension. In 37 patients (= 35%) it decreased, out of them in 13 to normal values. Only in 15 patients (= 14%) the PAP did not change. We conclude, that a single measurement of the pulmonary arterial pressure can only be a marker of the general prognosis in COLD, but not of the individual prognosis. So we need further follow-up studies for the correct assessment of the individual prognosis dependent on the clinical state in each case.
该研究展示了203例慢性阻塞性肺疾病（COLD）患者在4至6年随访期内的结果。调查内容包括临床状况、肺功能测试、血气分析以及肺动脉压（PAP）测量。这203例患者中有106例在4至6年内接受了3次调查。临床状况、氧分压和气道阻力与静息及运动状态下的肺动脉压显示出最佳相关性。54例患者（占51%）的肺动脉压升高至肺动脉高压。37例患者（占35%）的肺动脉压下降，其中13例降至正常水平。只有15例患者（占14%）的肺动脉压未发生变化。我们得出结论，单次测量肺动脉压仅可作为慢性阻塞性肺疾病总体预后的一个指标，而非个体预后的指标。因此，我们需要进一步的随访研究，以便根据每个病例的临床状况正确评估个体预后。
