感染雪蟹（Chionoecetes opilio）的尼马病毒——雪蟹杆状病毒的基因组序列
Genome sequence of Chionoecetes opilio bacilliform virus, a nimavirus infecting the snow crab Chionoecetes opilio.
作者信息
Kawato Satoshi, Fujishima Shoya, Nozaki Reiko, Kondo Hidehiro, Isshiki Tadashi, Hirono Ikuo
机构信息
Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Graduate School of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie, Japan.
出版信息
Arch Virol. 2023 Mar 5;168(3):101. doi: 10.1007/s00705-023-05731-8.
Nimaviridae (class Naldaviricetes) is a family of double-stranded DNA viruses infecting crustaceans, with the only officially recognized representative being white spot syndrome virus (WSSV). Chionoecetes opilio bacilliform virus (CoBV) was isolated as the causative agent of milky hemolymph disease in the snow crab Chionoecetes opilio, an economically important crustacean in the northwestern Pacific. Here, we present the complete genome sequence of CoBV and show that it is unambiguously a nimavirus. The CoBV genome is a 240-kb circular DNA molecule with 40% GC content that encodes 105 proteins, including 76 WSSV orthologs. Phylogenetic analysis based on eight naldaviral core genes established that CoBV is a member of the family Nimaviridae. The availability of the CoBV genome sequence provides a deeper understanding of CoBV pathogenicity and nimavirus evolution.
尼马病毒科（纳尔德病毒纲）是一类感染甲壳类动物的双链DNA病毒，唯一被官方认可的代表是白斑综合征病毒（WSSV）。雪蟹杆状病毒（CoBV）是从太平洋西北部一种具有重要经济价值的甲壳类动物——雪蟹（Chionoecetes opilio）中分离出来的，它是雪蟹乳白血淋巴病的病原体。在此，我们公布了CoBV的完整基因组序列，并表明它无疑是一种尼马病毒。CoBV基因组是一个240 kb的环状DNA分子，GC含量为40%，编码105种蛋白质，其中包括76种与WSSV直系同源的蛋白。基于8个纳尔德病毒核心基因的系统发育分析确定CoBV是尼马病毒科的成员。CoBV基因组序列的获得为深入了解CoBV的致病性和尼马病毒的进化提供了帮助。
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