LIME TECHNOLOGY IKE, Ioannina, Greece.
LIME TECHNOLOGY IKE, Ioannina, Greece.
Comput Methods Programs Biomed. 2023 Apr;232:107448. doi: 10.1016/j.cmpb.2023.107448. Epub 2023 Feb 26.
This study presents the EDIT software, a tool for the visualization of the urinary bladder anatomy in the 3D space and for its semi-automatic 3D reconstruction.
The inner bladder wall was computed by applying a Region of Interest (ROI) feedback-based active contour algorithm on the ultrasound images while the outer bladder wall was calculated by expanding the inner borders to approach the vascularization area on the photoacoustic images. The validation strategy of the proposed software was divided into two processes. Initially, the 3D automated reconstruction was performed on 6 phantom objects of different volume in order to compare the software computed volumes of the models with the true volumes of phantoms. Secondly, the in-vivo 3D reconstruction of the urinary bladder for 10 animals with orthotopic bladder cancer, which range in different stages of tumor progression was performed.
The results showed that the minimum volume similarity of the proposed 3D reconstruction method applied on phantoms is 95.59%. It is noteworthy to mention that the EDIT software enables the user to reconstruct the 3D bladder wall with high precision, even if the bladder silhouette has been significantly deformed by the tumor. Indeed, by taking into account the dataset of the 2251 in-vivo ultrasound and photoacoustic images, the presented software performs segmentation with dice similarity 96.96% and 90.91% for the inner and the outer borders of the bladder wall, respectively.
This study delivers the EDIT software, a novel software tool that uses ultrasound and photoacoustic images to extract different 3D components of the bladder.
本研究介绍了 EDIT 软件，这是一种用于在 3D 空间可视化膀胱解剖结构并进行半自动化 3D 重建的工具。
通过在超声图像上应用基于感兴趣区域（ROI）反馈的主动轮廓算法来计算膀胱内表面，而通过向外扩展内边界来接近光声图像上的血管化区域来计算膀胱外表面。所提出软件的验证策略分为两个过程。首先，对 6 个不同体积的幻影物体进行了 3D 自动重建，以便比较软件计算的模型体积与幻影的真实体积。其次，对 10 只患有原位膀胱癌的动物进行了体内 3D 重建，这些动物处于肿瘤进展的不同阶段。
结果表明，应用于幻影的建议 3D 重建方法的最小体积相似度为 95.59%。值得注意的是，EDIT 软件使用户能够高精度地重建 3D 膀胱壁，即使膀胱轮廓因肿瘤而严重变形。实际上，通过考虑 2251 个体内超声和光声图像的数据集，所提出的软件在膀胱壁的内边界和外边界的分割中分别达到了 96.96%和 90.91%的骰子相似性。
本研究提供了 EDIT 软件，这是一种使用超声和光声图像提取膀胱不同 3D 成分的新型软件工具。
