Buhles N, Hölzel C, Spiteller G, Holzmann H, Altmeyer P
Universitäts-Hautklinik im St. Josef-Hospital, Bochum.
Z Hautkr. 1987 Sep 15;62(18):1356-8, 1363.
The corticosteroid and androgen metabolites in the urine of 37 test subjects (11 healthy volunteers, 16 patients with eczema, and 10 patients with psoriasis) were investigated by means of gas chromatography and mass spectrometry. In addition, we studied the cortisol and testosterone levels in the plasma by radioimmunoassay. Those patients who had been treated with corticosteroids during the last two weeks were excluded. Our findings revealed that the excretion rate of steroid metabolites was significantly reduced in dermatological patients. The excretion rate of corticosteroids in urine was decreased an average of 25% (eczema) and 29% (psoriasis). The reduction of the androgen metabolites amounted to 26% and 31%. Cortisol and testosterone levels in the plasma were normal in all the cases.
通过气相色谱法和质谱法对37名受试对象（11名健康志愿者、16名湿疹患者和10名银屑病患者）尿液中的皮质类固醇和雄激素代谢物进行了研究。此外，我们通过放射免疫分析法研究了血浆中的皮质醇和睾酮水平。排除了在过去两周内接受过皮质类固醇治疗的患者。我们的研究结果显示，皮肤病患者的类固醇代谢物排泄率显著降低。尿液中皮质类固醇的排泄率平均降低了25%（湿疹）和29%（银屑病）。雄激素代谢物的降低幅度分别为26%和31%。所有病例的血浆皮质醇和睾酮水平均正常。
